Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

LTK (P29376) - Overview - Molecular Target Synopsis


LTK, Leukocyte tyrosine kinase receptor
Enzyme Classification
UniProt P29376

Also Known as LTK_HUMAN, LTK, TYK1

Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Homodimer when bound to ligand (Probable). Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: LTK is active in the following subcellular-locations: membrane.
GO terms: LTK is active in the following subcellular-locations: integral component of plasma membrane, membrane, plasma membrane, receptor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project LTK has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H522, COLO205, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-484, A4/Fuk, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

RNA Interference

LTK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OAW42, KNS42. (see details)

3D Structures

At greater than 75% identity similarity to LTK there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

LTK is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

LTK has been screened with 535 compounds (960 bioactivities), 15 compounds have bioactivities that show binding affinity of <= 500nM (19 bioactivities). (see details)