Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CRABP2 (P29373) - Overview - Molecular Target Synopsis

Protein


CRABP2, Cellular retinoic acid-binding protein 2
UniProt P29373

Also Known as RABP2_HUMAN, CRABP2

Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. Interacts with RXR and RARA (By similarity). Interacts with importin alpha.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
138ENSG00000143320ENST00000368222, ENST00000368221ENSP00000357205, ENSP00000357204P29373-1
89ENSG00000143320ENST00000368220ENSP00000357203

Sub-cellular localization


UniProt: CRABP2 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, nucleus.
GO terms: CRABP2 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, extracellular exosome, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CRABP2 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, HT29, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, HCC1954, HGC-27

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, SK-N-SH

(see details)

3D Structures


For CRABP2 there are:
71 structures (93 chains) solved
58 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CRABP2 has been screened with 4 compounds (18 bioactivities). (see details)