Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTPN6 (P29350) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEQ_A 36.18 1.0E-49 1.97Å TRS JL4 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMX_A 59.69 0 2.42Å DYV 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QGB_A 36.18 1.0E-49 1.55Å TRS JQA 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEX_A 36.18 1.0E-49 1.67Å TRS JMM 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDJ_A 36.18 1.0E-49 1.76Å JFP TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4OHD_A 59.2 0 2.7Å - 2014-09-24
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFI_A 36.18 1.0E-49 1.68Å JOG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRS (Q13332) - HUMAN 4BPC_A 40.41 8.0E-53 2.1Å - 2013-07-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDE_A 36.18 1.0E-49 1.76Å AWD TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMW_A 59.69 0 2.099Å 5OD DZS 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I4H_A 39.92 3.0E-50 2.14Å UA1 2006-08-29
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMV_B 59.69 0 2.05Å DZS 2018-01-17
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5I6V_A 59.5 0 1.87Å - 2016-04-13
SH2 domain (100%) (view alignment) PTPN11 (Q06124) cagA (P55980) HUMAN 5X7B_A 58.99 1.0E-71 2.45Å - 2017-09-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5IBS_A 59.5 0 2.316Å - 2016-04-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG2_A 36.18 1.0E-49 2.12Å TRS H5A 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG9_A 36.18 1.0E-49 1.67Å JQ4 TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4PVG_A 60 9.0E-100 2.1Å 2WT 2015-04-15
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFR_A 36.18 1.0E-49 1.62Å TRS JKA 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MD9_A 59.69 0 2.12Å JEJ 2019-02-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4OHL_A 59.2 0 2.4Å - 2014-09-24
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMR_B 59.69 0 2.205Å DZV 2018-01-17
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDB_A 59.69 0 2.34Å JE4 2019-02-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MD7_B 59.69 0 1.96Å JE1 2019-02-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDA_B 59.69 0 2.21Å JED 2019-02-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2H02_B 39.92 3.0E-50 2.15Å 2UN 2006-06-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BN5_B 59.5 0 2.218Å DZJ 2017-12-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 3ZM3_A 59.36 1.0E-94 1.5Å - 2014-04-23
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4DGX_A 59.2 0 2.3Å - 2013-03-06
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5IBM_A 59.5 0 2.16Å - 2016-04-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFU_A 36.18 1.0E-49 1.61Å TRS JO7 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEL_A 36.18 1.0E-49 1.65Å TRS JKS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRM (P28827) - HUMAN 1RPM_A 41.18 1.0E-50 2.3Å - 1998-04-01
Protein-tyrosine phosphatase (100%) (view alignment) PTPRS (Q13332) - HUMAN 2FH7_A 40.41 4.0E-52 1.81Å - 2006-01-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE0_A 36.18 1.0E-49 1.98Å TRS JGS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QGC_A 36.18 1.0E-49 1.59Å JQD TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEB_A 36.18 1.0E-49 1.73Å JHV TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEK_A 36.18 1.0E-49 1.9Å ES7 TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 2SHP_A 59.31 0 2Å CAT 1999-02-16
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEU_A 36.18 1.0E-49 1.73Å JKY TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRM (P28827) - HUMAN 1RPM_B 41.18 1.0E-50 2.3Å - 1998-04-01
SH2 domain (100%) (view alignment) PTPN6 (P29350) KLRC1 (P26715) HUMAN 2RMX_A 100 5.0E-11 - 2008-12-02
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMQ_D 57.88 1.0E-19 2.9Å - 2018-11-14
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG8_A 36.18 1.0E-49 1.63Å JPV TRS 2018-10-10
SH2 domain (100%) (view alignment) PTPN6 (P29350) KLRC1 (P26715) HUMAN 2YU7_A 100 5.0E-11 - 2008-04-15
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 3O5X_A 59.48 6.0E-91 1.66Å JZG 2010-08-11
SH2 domain (100%) (view alignment) PTPN11 (Q06124) cagA (P55980) HUMAN 5X94_A 58.99 1.0E-71 2.6Å - 2017-09-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPRK (Q15262) - HUMAN 2C7S_A 42.65 2.0E-54 1.95Å - 2007-01-02
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2AHS_A 39.84 9.0E-50 2.1Å - 2005-08-09
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4NWG_B 58.72 0 2.45Å - 2014-12-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF2_A 36.18 1.0E-49 1.77Å TRS JMA 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDX_A 36.18 1.0E-49 2.06Å JGM TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 3B7O_A 56.82 6.0E-100 1.6Å MLT 2007-11-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 2JJD_D 39.87 9.0E-52 3.2Å - 2008-04-08
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG5_A 36.18 1.0E-49 2.07Å TRS 0R0 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 6B8X_A 36.18 1.0E-49 1.74Å - 2018-06-20
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QES_A 36.18 1.0E-49 1.74Å 6RO TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEM_A 36.18 1.0E-49 1.75Å JLG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEI_A 36.18 1.0E-49 1.74Å JJM TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRT (O14522) - HUMAN 2OOQ_A 41.08 3.0E-54 1.8Å B3P 2007-02-20
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2HC2_A 39.84 2.0E-49 1.4Å - 2006-06-27
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEH_A 36.18 1.0E-49 1.94Å JJG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 6D4D_B 41.78 2.0E-50 1.76Å - 2018-10-17
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMS_A 58.94 0 2.68Å 5OD 2018-11-14
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEE_A 36.18 1.0E-49 1.93Å TRS JJ4 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 6B8E_A 36.18 1.0E-49 1.82Å TRS 2018-06-20
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF9_A 36.18 1.0E-49 1.93Å JNM TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEV_A 36.18 1.0E-49 1.72Å TRS JKV 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEJ_A 36.18 1.0E-49 1.92Å TRS JKP 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE6_A 36.18 1.0E-49 1.77Å TRS JHA 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4GWF_A 58.72 0 2.1Å PGE 2013-09-04
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFS_A 36.18 1.0E-49 1.85Å TRS JJY 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFC_A 36.18 1.0E-49 1.84Å JNA TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFQ_A 36.18 1.0E-49 1.62Å JK7 TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4NWF_B 58.72 0 2.1Å - 2014-12-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I3U_A 39.92 3.0E-50 1.85Å - 2006-08-29
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 4GRY_A 100 0 1.7Å - 2012-12-19
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 3MOW_A 59.48 6.0E-91 2.3Å B2B 2011-05-04
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDI_A 36.18 1.0E-49 1.62Å JFM TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4H34_A 58.72 0 2.7Å - 2013-10-02
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 2JJD_F 39.87 9.0E-52 3.2Å - 2008-04-08
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 1FPR_A 100 0 2.5Å - 2001-03-07
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMQ_C 57.88 1.0E-19 2.9Å - 2018-11-14
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMY_B 59.69 0 2.085Å 5OD DYV 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 3ZM1_A 59.72 4.0E-96 1.4Å - 2014-04-23
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF0_A 36.18 1.0E-49 1.71Å TRS JMG 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFG_A 36.18 1.0E-49 1.65Å TRS JOA 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFV_A 36.18 1.0E-49 1.64Å JK7 TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEZ_A 36.18 1.0E-49 1.65Å TRS 2O8 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRG (P23470) - HUMAN 3QCL_A 40.14 9.0E-50 2.4Å NXV 2011-12-28
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFP_A 36.18 1.0E-49 1.77Å TRS JJY 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 2JJD_E 39.87 9.0E-52 3.2Å - 2008-04-08
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDC_A 59.69 0 2.14Å JEA 2019-02-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDW_A 36.18 1.0E-49 2.21Å TRS JGJ 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4OHE_A 59.2 0 2.5Å - 2014-09-24
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 3PS5_A 100 0 3.1Å - 2011-04-20
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 4HJQ_B 100 0 1.8Å - 2013-04-03
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEC_A 36.18 1.0E-49 1.67Å 02S TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDM_A 36.18 1.0E-49 2.65Å AW7 TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CRF_B 59.5 0 2.62Å - 2018-11-07
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMR_A 58.94 0 2.21Å 5OD 2018-11-14
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDF_A 36.18 1.0E-49 1.71Å AWG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRT (O14522) - HUMAN 2OOQ_B 41.08 3.0E-54 1.8Å B3P 2007-02-20
Protein-tyrosine phosphatase (100%) (view alignment) Ptprs (Q64605) - NORWAY RAT 2NV5_C 41.09 2.0E-51 2Å - 2006-11-21
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CRG_A 59.5 0 2.75Å 5OD 2018-11-07
Protein-tyrosine phosphatase (100%) (view alignment) PTPRG (P23470) - HUMAN 3QCN_A 40.14 9.0E-50 2.41Å - 2011-12-28
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5EHP_A 59.69 0 1.85Å 5OA 2016-07-06
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMV_A 59.69 0 2.05Å DZS 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 4GRZ_A 100 0 1.37Å - 2012-12-19
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDD_B 59.69 0 2.05Å JE7 2019-02-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2H04_A 39.92 3.0E-50 2.3Å 4UN 2006-06-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPRF (P10586) - HUMAN 1LAR_A 42.45 3.0E-50 2Å - 2000-04-25
SH2 domain (100%) (view alignment) PTPN11 (Q06124) cagA (P55980) HUMAN 5X94_B 58.99 1.0E-71 2.6Å - 2017-09-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE9_A 36.18 1.0E-49 1.69Å TRS JHP 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG7_A 36.18 1.0E-49 1.81Å TRS JKJ 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I5X_A 39.92 3.0E-50 1.7Å UA5 2006-09-05
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMP_B 58.94 0 1.8Å - 2018-11-14
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDZ_A 36.18 1.0E-49 2.14Å JGP TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 4HJP_A 100 0 1.399Å - 2013-04-03
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 6D4D_A 41.78 2.0E-50 1.76Å - 2018-10-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFA_A 36.18 1.0E-49 1.74Å TRS JNG 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEP_A 36.18 1.0E-49 1.77Å TRS JL7 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE1_A 36.18 1.0E-49 1.68Å JGV TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 1GWZ_A 100 0 2.5Å - 1999-08-22
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 2JJD_C 39.87 9.0E-52 3.2Å - 2008-04-08
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I3R_A 39.92 3.0E-50 1.85Å - 2006-08-29
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMU_A 59.69 0 2.116Å 5OD DZV 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE5_A 36.18 1.0E-49 1.77Å TRS JH7 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QGF_A 36.18 1.0E-49 1.51Å TRS F8D 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMQ_A 57.88 1.0E-19 2.9Å - 2018-11-14
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG4_A 36.18 1.0E-49 1.79Å JPD TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDK_A 36.18 1.0E-49 1.55Å JFS TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 4GS0_B 100 0 1.796Å - 2012-12-19
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6ATD_A 59.5 0 2.5Å - 2018-07-11
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFB_A 36.18 1.0E-49 1.85Å JND TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG1_A 36.18 1.0E-49 2.21Å JKG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDN_A 36.18 1.0E-49 1.82Å JFY TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEW_A 36.18 1.0E-49 1.83Å TRS JMV 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEY_A 36.18 1.0E-49 1.77Å TRS JMJ 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF8_A 36.18 1.0E-49 1.99Å TRS JNP 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5EHR_B 59.69 0 1.7Å 5OD 2016-06-29
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDG_A 36.18 1.0E-49 1.79Å TRS AWS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFW_A 36.18 1.0E-49 1.66Å TRS JKA 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE8_A 36.18 1.0E-49 1.81Å JHJ TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CRF_A 59.5 0 2.62Å - 2018-11-07
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDA_A 59.69 0 2.21Å JED 2019-02-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4NWG_A 58.72 0 2.45Å - 2014-12-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDY_A 36.18 1.0E-49 1.83Å TRS MPV 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF1_A 36.18 1.0E-49 1.84Å JMD TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFD_A 36.18 1.0E-49 1.69Å TRS JN1 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFE_A 36.18 1.0E-49 1.56Å JJP TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 3ZM0_A 59.72 4.0E-96 1.5Å - 2014-04-23
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFT_A 36.18 1.0E-49 1.96Å TRS JOY 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE7_A 36.18 1.0E-49 1.71Å TRS JHD 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFK_A 36.18 1.0E-49 1.59Å JJP TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMX_B 59.69 0 2.42Å DYV 2018-01-17
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5XZR_A 59.01 0 2.8Å 8J6 2017-12-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5IBS_B 59.5 0 2.316Å - 2016-04-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG0_A 36.18 1.0E-49 1.75Å JP4 TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMR_A 59.69 0 2.205Å DZV 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFL_A 36.18 1.0E-49 1.82Å TRS JOM 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) Ptprs (Q64605) - NORWAY RAT 2NV5_A 41.09 2.0E-51 2Å - 2006-11-21
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4OHH_A 59.2 0 2.7Å - 2014-09-24
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I4E_B 39.92 3.0E-50 1.75Å - 2006-08-29
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4OHL_B 59.2 0 2.4Å - 2014-09-24
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 4GS0_A 100 0 1.796Å - 2012-12-19
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDV_A 36.18 1.0E-49 1.77Å GQP TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMU_B 59.69 0 2.116Å 5OD DZV 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 6B8Z_A 36.18 1.0E-49 1.8Å FRJ 2018-06-20
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFF_A 36.18 1.0E-49 1.7Å JMY TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDH_A 36.18 1.0E-49 1.68Å JFJ TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2H02_A 39.92 3.0E-50 2.15Å 2UN 2006-06-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF4_A 36.18 1.0E-49 1.83Å JLV TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDU_A 36.18 1.0E-49 1.67Å TRS GV1 2018-10-10
SH2 domain (100%) (view alignment) PTPN6 (P29350) - HUMAN 1X6C_A 100 5.0E-11 - 2005-11-17
SH2 domain (100%) (view alignment) PTPN11 (Q06124) TXNIP (Q9H3M7) HUMAN 5DF6_A 58.9 9.0E-73 1.78Å - 2015-09-23
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MD7_A 59.69 0 1.96Å JE1 2019-02-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPRF (P10586) - HUMAN 1LAR_B 42.45 3.0E-50 2Å - 2000-04-25
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5I6V_B 59.5 0 1.87Å - 2016-04-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFO_A 36.18 1.0E-49 1.85Å 8H8 TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 2SHP_B 59.31 0 2Å CAT 1999-02-16
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDT_A 36.18 1.0E-49 1.82Å TRS GUY 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 3ZM2_A 59.72 4.0E-96 1.5Å - 2014-04-23
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2HC1_A 39.84 2.0E-49 1.3Å - 2006-06-27
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4OHI_A 59.2 0 2.2Å - 2014-09-24
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QGA_A 36.18 1.0E-49 1.65Å TRS JQ7 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2AHS_B 39.84 9.0E-50 2.1Å - 2005-08-09
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 2B3O_A 100 0 2.8Å - 2005-10-25
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5EHP_B 59.69 0 1.85Å 5OA 2016-07-06
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEF_A 36.18 1.0E-49 1.6Å TRS JJ7 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFJ_A 36.18 1.0E-49 1.95Å JOJ TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4DGP_A 59.39 0 2.3Å - 2013-03-06
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFN_A 36.18 1.0E-49 1.67Å JOV TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN12 (Q05209) - HUMAN 5HDE_A 40.23 1.0E-49 1.62Å CSP 2017-01-18
Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4RDD_A 59.48 7.0E-91 1.6Å 3LU 2015-07-01
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4H1O_A 58.72 0 2.2Å - 2013-09-11
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFZ_A 36.18 1.0E-49 1.72Å TRS GW1 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFY_A 36.18 1.0E-49 1.77Å JO1 TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDR_A 36.18 1.0E-49 1.78Å TRS 6SU 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QET_A 36.18 1.0E-49 1.72Å DSJ TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MD9_B 59.69 0 2.12Å JEJ 2019-02-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QGE_A 36.18 1.0E-49 1.7Å JKG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF6_A 36.18 1.0E-49 1.77Å JNY TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEA_A 36.18 1.0E-49 1.74Å TRS JHS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFX_A 36.18 1.0E-49 1.82Å JO4 TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF3_A 36.18 1.0E-49 1.56Å JLY TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CRG_B 59.5 0 2.75Å 5OD 2018-11-07
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMQ_B 57.88 1.0E-19 2.9Å - 2018-11-14
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDO_A 36.18 1.0E-49 1.79Å JG4 TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4GWF_B 58.72 0 2.1Å - 2013-09-04
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMW_B 59.69 0 2.099Å 5OD DZS 2018-01-17
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFH_A 36.18 1.0E-49 1.59Å TRS JOD 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) Ptprs (B0V2N1) - MOUSE 3SR9_A 40.75 5.0E-54 2.4Å - 2012-05-30
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG6_A 36.18 1.0E-49 1.73Å JPG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF7_A 36.18 1.0E-49 1.75Å TRS JNV 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDQ_A 36.18 1.0E-49 1.57Å JGD TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDB_B 59.69 0 2.34Å JE4 2019-02-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6ATD_B 59.5 0 2.5Å - 2018-07-11
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDL_A 36.18 1.0E-49 1.83Å JFV TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE3_A 36.18 1.0E-49 1.74Å TRS JH1 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QED_A 36.18 1.0E-49 1.76Å TRS 7MU 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 2JJD_A 39.87 9.0E-52 3.2Å - 2008-04-08
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6CMP_A 58.94 0 1.8Å - 2018-11-14
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BN5_A 59.5 0 2.218Å DZJ 2017-12-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEN_A 36.18 1.0E-49 1.78Å JLD TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6BMY_A 59.69 0 2.085Å 5OD DYV 2018-01-17
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 4NWF_A 58.72 0 2.1Å - 2014-12-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QGD_A 36.18 1.0E-49 1.66Å TRS JKJ 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I4G_A 39.92 3.0E-50 1.65Å UA1 2006-08-29
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QFM_A 36.18 1.0E-49 1.83Å TRS JOP 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 6B8T_A 36.18 1.0E-49 1.85Å TRS 2018-06-20
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDP_A 36.18 1.0E-49 1.74Å JGA TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRE (P23469) - HUMAN 2JJD_B 39.87 9.0E-52 3.2Å - 2008-04-08
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QDS_A 36.18 1.0E-49 1.75Å JGG TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QF5_A 36.18 1.0E-49 1.73Å JLM TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I5X_B 39.92 3.0E-50 1.7Å UA5 2006-09-05
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDD_A 59.69 0 2.05Å JE7 2019-02-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE4_A 36.18 1.0E-49 1.85Å TRS JH4 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN6 (P29350) - HUMAN 4HJQ_A 100 0 1.8Å - 2013-04-03
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QER_A 36.18 1.0E-49 1.73Å TRS JL1 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QE2_A 36.18 1.0E-49 1.79Å JGY TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 6MDC_B 59.69 0 2.14Å JEA 2019-02-13
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5EHR_A 59.69 0 1.7Å 5OD 2016-06-29
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I3R_B 39.92 3.0E-50 1.85Å - 2006-08-29
Protein-tyrosine phosphatase (100%) (view alignment) PTPRB (P23467) - HUMAN 2I4E_A 39.92 3.0E-50 1.75Å - 2006-08-29
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEG_A 36.18 1.0E-49 1.97Å GRY TRS 2018-10-10
SH2 domain (100%), Protein-tyrosine phosphatase (100%) (view alignment) PTPN11 (Q06124) - HUMAN 5IBM_B 59.5 0 2.16Å - 2016-04-13
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QG3_A 36.18 1.0E-49 1.65Å JP7 TRS 2018-10-10
Protein-tyrosine phosphatase (100%) (view alignment) Ptprs (Q64605) - NORWAY RAT 2NV5_B 41.09 2.0E-51 2Å - 2006-11-21
Protein-tyrosine phosphatase (100%) (view alignment) PTPN1 (P18031) - HUMAN 5QEO_A 36.18 1.0E-49 1.72Å JLA TRS 2018-10-10