Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
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PTPN6 (P29350) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria5
Chains with at least one site assessed as druggable using the relaxed criteria13


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2RMX_A Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 64.7 33.9 Yes No
2 empty 2.26 54.7 19.3 No No
3 empty 2.2 58.6 19.3 No No
4 empty 1.82 61.1 16.4 No No
5 empty 2.37 69.6 12.7 No No
6 empty 2.41 63.1 10.7 No No
7 empty 2.1 62.3 12.7 No No
8 empty 2.84 53.8 9.3 No No
9 empty 3.16 59.3 7.6 No No
10 empty 2.16 61 7.4 No No
2YU7_A Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 56 30 Yes No
2 empty 2.12 61.8 30.5 No No
3 empty 2.11 54 17.8 No No
4 empty 2.47 61.2 15.9 No No
5 empty 1.92 69.4 8.4 No No
6 empty 2.55 66.2 9.4 No No
7 empty 2.33 61.2 6.9 No No
8 empty 2.21 88.3 9.8 Yes No
9 empty 2.6 58.1 5.8 No No
10 empty 2.6 65.2 5.5 No No
4GRY_A Tyrosine-protein phosphatase non-receptor type 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 66.2 42.6 Yes Yes
2 empty 2.25 65.2 34.7 No No
3 empty 2.19 59.3 22.9 No No
4 empty 2.44 66.2 16.3 No No
5 empty 2.43 76 9.3 No No
6 empty 1.9 63.5 11.7 No No
7 empty 2.24 63.1 11 No No
8 empty 2.03 68.1 10.8 No No
9 empty 2.22 54.9 11.7 No No
10 empty 2.21 60.9 10.5 No No
1FPR_A Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 65.8 43.8 Yes No
2 empty 2.28 64.1 34.7 No No
3 empty 2.3 64.6 19 No No
4 empty 2.34 63.2 20.9 No No
5 empty 2.11 56.4 24.5 No No
6 empty 1.89 60 14.9 No No
7 empty 2.11 69.6 10.9 No No
8 empty 2.44 69.6 14.6 No No
9 empty 2.12 63.1 13.6 No No
10 empty 1.73 60.8 16.3 No No
3PS5_A Tyrosine-protein phosphatase non-receptor type 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 66.3 37.1 Yes Yes
2 empty 2.05 63.4 42 No No
3 empty 2.18 73.3 24.8 No No
4 bound 2.52 65.8 31.6 No No
5 empty 2 59.8 32.3 No No
6 empty 2.2 61.4 25.8 No No
7 bound 2.06 72.6 19 No No
8 empty 2.08 63.2 23.7 No No
9 empty 2.21 56.4 17.6 No No
10 bound 2.33 61.4 23.4 No No
4HJQ_B Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 66.4 31 Yes No
2 empty 1.99 68.8 19.3 No No
3 empty 2.23 58.3 24.6 No No
4 empty 2.36 60.9 15.9 No No
5 empty 2.39 56.5 20.7 No No
6 empty 2.47 73.3 11.4 No No
7 empty 2.12 62 13.8 No No
8 empty 2.41 66.9 12 No No
9 empty 2.41 70.7 13.6 No No
10 empty 2.28 66.9 13.4 No No
4GRZ_A Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 65.1 28 Yes No
2 empty 1.92 69.6 25.6 No No
3 empty 2.44 61.1 34.4 No No
4 empty 2.14 61.8 26 No No
5 empty 2.45 77.2 10.5 No No
6 empty 2.54 68.8 12.9 No No
7 empty 2.57 63.2 12.7 No No
8 empty 2.09 64.8 12.7 No No
9 empty 1.84 64.5 15.2 No No
10 empty 2.47 70 11.5 No No
4HJP_A Tyrosine-protein phosphatase non-receptor type 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 66.1 48.4 Yes Yes
2 empty 2.35 66.4 34.6 No No
3 empty 2.6 61.4 25 No No
4 empty 2.02 59.2 23.3 No No
5 empty 2.24 72 11.5 No No
6 empty 2.21 69.3 17.4 No No
7 empty 2.08 60.8 14.9 No No
8 empty 2.18 67.4 10.6 No No
9 empty 2.41 65.9 11.4 No No
10 empty 1.96 55.9 14 No No
1GWZ_A Tyrosine-protein phosphatase non-receptor type 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 67.9 45.9 Yes Yes
2 empty 2.16 66.4 26.6 No No
3 empty 1.94 49.2 19.9 No No
4 empty 1.97 61.9 23.2 No No
5 empty 1.94 57 12.1 No No
6 empty 2.47 62.5 15.3 No No
7 empty 2.03 69.4 15.3 No No
8 empty 2.18 56.6 16.8 No No
9 empty 2.61 63.2 21.9 No No
10 empty 2.44 69.8 11.8 No No
4GS0_B Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 66.7 33.9 Yes No
2 empty 2.35 72.7 21.9 No No
3 empty 2.24 58.4 22.2 No No
4 empty 2.06 66.9 14 No No
5 empty 2.65 61.9 15.2 No No
6 empty 2.42 80.3 12.9 No No
7 empty 2.11 72.8 14 No No
8 empty 2.65 64 9.3 No No
9 empty 2.37 63 13.4 No No
10 empty 2.11 68.1 8.5 No No
4GS0_A Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 64.5 25.3 Yes No
2 empty 1.56 60.2 28.7 No No
3 empty 2.13 61.7 26.1 No No
4 empty 2.36 77.9 13.1 No No
5 empty 2.32 68.9 12.5 No No
6 empty 2.38 64.3 12.7 No No
7 empty 2.46 62.6 13.7 No No
8 empty 2.19 59 12.4 No No
9 empty 2.16 66.3 12 No No
10 empty 2.35 80.3 11.6 No No
1X6C_A Tyrosine-protein phosphatase non-receptor type 6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 61.4 20.6 No No
2 empty 2.23 59.7 20.8 No No
3 empty 2.3 57.8 21.1 No No
4 empty 1.84 53.3 16.9 No No
5 empty 2.63 67.8 15.4 No No
6 empty 2.13 67.9 12.3 No No
7 empty 2.42 60.7 11 No No
8 empty 2.46 57 12.6 No No
9 empty 1.72 67.5 9 No No
10 empty 3.04 66.7 11.2 No No
2B3O_A Tyrosine-protein phosphatase non-receptor type 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 72.3 50.5 Yes Yes
2 empty 2.27 62.7 42.6 No No
3 empty 2.36 65.8 30 No No
4 empty 2.21 70.3 26.6 No No
5 empty 2.3 71.4 14.9 No No
6 empty 2 62.8 22.3 No No
7 empty 2.19 61.1 14.2 No No
8 empty 2.53 63.6 15.9 No No
9 empty 2.25 61 16 No No
10 empty 2.22 61.4 12.7 No No
4HJQ_A Tyrosine-protein phosphatase non-receptor type 6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 65.4 37.6 Yes No
2 empty 2.09 73.5 20 No No
3 empty 2.18 62.1 25.8 No No
4 empty 2.43 69.3 12.8 No No
5 empty 2.38 64.8 14.4 No No
6 empty 2.53 65.2 19 No No
7 empty 2.28 66.7 18.7 No No
8 empty 2.47 72 10.2 No No
9 empty 2.08 67.5 11.3 No No
10 empty 2.41 69.9 12.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed11
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria9

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1FPR_A (59949) Tyrosine-protein phosphatase non-receptor type 6 (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 2.5Å Yes No
1GWZ_A (32685) Tyrosine-protein phosphatase non-receptor type 6 (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 2.5Å Yes Yes
1X6C_A (3020413) Tyrosine-protein phosphatase non-receptor type 6 SH2-like, SH2 domain, UNMATCHED No No
2B3O_A (3040856) Tyrosine-protein phosphatase non-receptor type 6 (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 2.8Å Yes No
2B3O_A (3040854) Tyrosine-protein phosphatase non-receptor type 6 SH2-like, SH2 domain, UNMATCHED 2.8Å Yes No
2B3O_A (3040855) Tyrosine-protein phosphatase non-receptor type 6 SH2-like, SH2 domain, UNMATCHED 2.8Å Yes No
2RMX_A (3200911) Tyrosine-protein phosphatase non-receptor type 6 SH2-like, SH2 domain, UNMATCHED Yes No
2YU7_A (3270934) Tyrosine-protein phosphatase non-receptor type 6 SH2-like, SH2 domain, UNMATCHED Yes No
3PS5_A (3670757) Tyrosine-protein phosphatase non-receptor type 6 SH2-like, SH2 domain, UNMATCHED 3.1Å No Yes
3PS5_A (3670756) Tyrosine-protein phosphatase non-receptor type 6 SH2-like, SH2 domain, UNMATCHED 3.1Å Yes No
3PS5_A (3670758) Tyrosine-protein phosphatase non-receptor type 6 (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 3.1Å Yes Yes
Ligand-based Druggability Score: 0.1
Ligand-based Druggability Score Percentile: 81%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PTPN6 is involved in 103 interactions in the network.


Druggability
Overall Druggability Percentile: 99.34
Druggability for Cancer Therapeutics: 98.79
Druggability for Other Therapeutics: 97.06
Cancer-Associated
Cancer-associated percentile : 99.18
Network Articulation Point
Is PTPN6 critical for communication in the network?


Detailed Graph Legend:Help