Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EPHA8 (P29322) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1X5L_A Ephrin type-A receptor 8 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 52.7 19.8 No No
2 empty 2.41 49.6 13.9 No No
3 empty 2.06 63.2 14.2 No No
4 empty 2.41 58.8 18.8 No No
5 empty 2.56 59.3 13.7 No No
6 empty 2.53 58.1 14.5 No No
7 empty 2.4 70.2 8.9 No No
8 empty 2.35 65.7 11.4 No No
9 empty 2.97 71.4 6.7 No No
10 empty 2.61 64.8 9.8 No No
3KUL_A Ephrin type-A receptor 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 65.2 41.6 Yes No
2 empty 2.31 57.9 26.8 No No
3 empty 1.74 55.1 19.8 No No
4 empty 2.04 64.1 17.2 No No
5 bound 1.54 68.9 13.2 No No
6 empty 2.4 73.6 8.6 No No
7 empty 1.58 68.9 11.9 No No
8 empty 2.24 60.8 13.5 No No
9 bound 1.7 62.1 12.6 No No
10 empty 2.53 55.5 9.3 No No
1UCV_A Ephrin type-A receptor 8 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.58 63.8 23.3 No No
2 empty 2.07 70.8 11.2 No No
3 empty 2.13 59.6 11.9 No No
4 empty 2.55 68.5 0 No No
5 empty 2.94 57.1 11.1 No No
6 empty 2.82 54.5 9.2 No No
7 empty 3.12 72.3 6 No No
8 empty 2.84 50.5 6.2 No No
9 empty 2.81 61.8 5.4 No No
10 empty 3.23 69.7 0 No No
3KUL_B Ephrin type-A receptor 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 68.1 40.6 Yes Yes
2 empty 2.41 75.9 20.1 No No
3 empty 2.18 60.2 31.2 No No
4 empty 1.92 62.7 21.6 No No
5 empty 1.88 76.8 18.7 No No
6 bound 2.07 75.2 12.5 No No
7 empty 2.54 69.1 14.2 No No
8 empty 1.71 66.2 11.7 No No
9 empty 2.35 69.8 9.8 No No
10 empty 2.44 61.7 15.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1UCV_A (99191) Ephrin type-A receptor 8 SAM domain-like, SAM/Pointed domain, SAM (sterile alpha motif) domain No No
1X5L_A (121713) Ephrin type-A receptor 8 Immunoglobulin-like beta-sandwich, Fibronectin type III, Fibronectin type III No No
3KUL_A (3510871) Ephrin type-A receptor 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.15Å Yes No
Ligand-based Druggability Score: -0.3
Ligand-based Druggability Score Percentile: 76%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


EPHA8 is involved in 13 interactions in the network.


Druggability
Overall Druggability Percentile: 99.90
Druggability for Cancer Therapeutics: 99.93
Druggability for Other Therapeutics: 96.34
Cancer-Associated
Cancer-associated percentile : 98.96
Network Articulation Point
Is EPHA8 critical for communication in the network?


Detailed Graph Legend:Help