Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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psaB (P29255) - Overview - Molecular Target Synopsis

Protein


psaB, Photosystem I P700 chlorophyll a apoprotein A2
Enzyme Classification 1.97.1.12
UniProt P29255

Also Known as PSAB_SYNY3, psaB

PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6. The PsaA/B heterodimer binds the P700 chlorophyll special pair and subsequent electron acceptors. PSI consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The cyanobacterial PSI reaction center is composed of one copy each of PsaA,B,C,D,E,F,I,J,K,L,M and X, and forms trimeric complexes.

6HQB
MONOMERIC CYANOBACTERIAL PHOTOSYSTEM I
RCSB/PDB
Inspect Structure
See all 3D Structures for psaB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
731P29255-1

Sub-cellular localization


UniProt: psaB is active in the following subcellular-locations: cellular thylakoid membrane.
GO terms: psaB is active in the following subcellular-locations: integral component of membrane, plasma membrane-derived photosystem I, thylakoid membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project psaB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For psaB there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

psaB is solved in complex with the approved drug(s):

PQN/PHYTONADIONE (4KT0_B, 4L6V_2, 4L6V_B, 4L6V_b, 5OY0_2, 5OY0_B, 5OY0_b, 6HQB_B),
BCR/BETA CAROTENE (4KT0_B, 4L6V_2, 4L6V_B, 4L6V_b, 5OY0_2, 5OY0_B, 5OY0_b, 6HQB_B).

(see details)
Molecular Target 3D Synopsis