Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

psaA (P29254) - Overview - Molecular Target Synopsis


psaA, Photosystem I P700 chlorophyll a apoprotein A1
Enzyme Classification
UniProt P29254

Also Known as PSAA_SYNY3, psaA

PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6. The PsaA/B heterodimer binds the P700 chlorophyll special pair and subsequent electron acceptors. PSI consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The cyanobacterial PSI reaction center is composed of one copy each of PsaA,B,C,D,E,F,I,J,K,L,M and X, and forms trimeric complexes.

Inspect Structure
See all 3D Structures for psaA

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: psaA is active in the following subcellular-locations: cellular thylakoid membrane.
GO terms: psaA is active in the following subcellular-locations: integral component of membrane, plasma membrane-derived photosystem I, thylakoid membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project psaA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For psaA there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

psaA is solved in complex with the approved drug(s):

PQN/PHYTONADIONE (4KT0_A, 4L6V_1, 4L6V_A, 4L6V_a, 5OY0_1, 5OY0_A, 5OY0_a, 6HQB_A),
BCR/BETA CAROTENE (4KT0_A, 4L6V_1, 4L6V_A, 4L6V_a, 5OY0_1, 5OY0_A, 5OY0_a, 6HQB_A).

(see details)
Molecular Target 3D Synopsis