Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IMPA1 (P29218) - Overview - Molecular Target Synopsis

Protein


IMPA1, Inositol monophosphatase 1
Enzyme Classification 3.1.3.25
UniProt P29218

Also Known as IMPA1_HUMAN, IMPA1, IMPA

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Homodimer.

6GIU
HUMAN IMPASE WITH L-690330
RCSB/PDB
Inspect Structure
See all 3D Structures for IMPA1

Isoforms / Transcripts (Protein Coding)


Drugs


IMPA1 is targeted by Approved Drug Lithium Citrate. (see details)
Lithium Citrate

Sub-cellular localization


UniProt: IMPA1 is active in the following subcellular-locations: cytoplasm.
GO terms: IMPA1 is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IMPA1 has gain in 17 cell-lines, loss in 2 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, HCT_116, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KG-1, HCC38, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, NHEK, AG445

(see details)

3D Structures


For IMPA1 there are:
11 structures (21 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


IMPA1 has been screened with compounds ( bioactivities). (see details)