Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TPP2 (P29144) - Overview - Molecular Target Synopsis

Protein


TPP2, Tripeptidyl-peptidase 2
Enzyme Classification 3.4.14.10
UniProt P29144

Also Known as TPP2_HUMAN, TPP2

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1262ENSG00000134900ENST00000376052ENSP00000365220
1249ENSG00000134900ENST00000376065ENSP00000365233P29144-1

Sub-cellular localization


UniProt: TPP2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TPP2 is active in the following subcellular-locations: cytoplasm, cytosol, nuclear body, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TPP2 has gain in 4 cell-lines, loss in 6 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, COLO205, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, TK, KMS-12-BM

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, AG445

(see details)

3D Structures


At greater than 35% identity similarity to TPP2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TPP2 has been screened with 1 compounds (1 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)