Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TPP2 (P29144) - Overview - Molecular Target Synopsis


TPP2, Tripeptidyl-peptidase 2
Enzyme Classification
UniProt P29144

Also Known as TPP2_HUMAN, TPP2

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: TPP2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TPP2 is active in the following subcellular-locations: cytoplasm, cytosol, nuclear body, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TPP2 has gain in 4 cell-lines, loss in 6 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HL_60, COLO205, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, TK, KMS-12-BM

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, AG445

(see details)

3D Structures

At greater than 35% identity similarity to TPP2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TPP2 has been screened with 1 compounds (1 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)