Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BRF1 (P29056) - Overview - Molecular Target Synopsis

Protein


BRF1, Transcription factor IIIB 70 kDa subunit
UniProt P29056

Also Known as TF3B_YEAST, BRF1, PCF4, TDS4

General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC. TFIIIB comprises the TATA-binding protein (TBP), the B-related factor (BRF) and the B" component (TFC5).

6CND
YEAST RNA POLYMERASE III NATURAL OPEN COMPLEX (NOC)
RCSB/PDB
Inspect Structure
See all 3D Structures for BRF1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
596P29056-1

Sub-cellular localization


UniProt: BRF1 is active in the following subcellular-locations: nucleus.
GO terms: BRF1 is active in the following subcellular-locations: nucleoplasm, nucleus, transcription factor TFIIIB complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BRF1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For BRF1 there are:
10 structures (13 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis