Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CD38 (P28907) - Overview - Molecular Target Synopsis

Protein


CD38, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Enzyme Classification 3.2.2.6
UniProt P28907

Also Known as CD38_HUMAN, CD38

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

6EDR
CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH 4'-THIORIBOSE NAD+
RCSB/PDB
Inspect Structure
See all 3D Structures for CD38

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CD38 is active in the following subcellular-locations: membrane.
GO terms: CD38 is active in the following subcellular-locations: basolateral plasma membrane, cell surface, extracellular exosome, integral component of membrane, membrane, nucleus, plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CD38 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, CCRF_CEM, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, MOLP-8, Daudi

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, SK-N-SH, NHLF

(see details)

3D Structures


For CD38 there are:
42 structures (86 chains) solved
34 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

CD38 is solved in complex with the approved drug(s):

NCA/NIACINAMIDE (3DZG_A, 3DZG_B, 3ROP_A, 3ROP_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CD38 has been screened with 215 compounds (266 bioactivities), 45 compounds have bioactivities that show binding affinity of <= 500nM (49 bioactivities). (see details)