Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ERCC5 (P28715) - Overview - Molecular Target Synopsis

Protein


ERCC5, DNA repair protein complementing XP-G cells
Enzyme Classification 3.1.-.-
UniProt P28715

Also Known as ERCC5_HUMAN, ERCC5, ERCM2, XPG, XPGC

Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Interacts with PCNA.

5EKF
6 RESIDUE FRAGMENT OF
DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS
IN THE STRUCTURE OF
CRYSTALLIZATION AND X-RAY DIFFRACTION DATA COLLECTION OF IMPORTIN- ALPHA FROM MUS MUSCULUS COMPLEXED WITH A XPG NLS PEPTIDE, FRAGMENT 1
RCSB/PDB
Inspect Structure
See all 3D Structures for ERCC5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ERCC5 is active in the following subcellular-locations: nucleus.
GO terms: ERCC5 is active in the following subcellular-locations: nucleoplasm, nucleotide-excision repair complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ERCC5 has gain in 4 cell-lines, loss in 6 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, COLO205, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 205, ML-2, COLO 206F

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HSMM, HeLa-S3

(see details)

3D Structures


For ERCC5 there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ERCC5 has been screened with 64 compounds (64 bioactivities), 29 compounds have bioactivities that show binding affinity of <= 500nM (29 bioactivities). (see details)