Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACK2 (P28523) - Overview - Molecular Target Synopsis

Protein


ACK2, Casein kinase II subunit alpha
Enzyme Classification 2.7.11.1
UniProt P28523

Also Known as CSK2A_MAIZE, ACK2

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. Tetramer of two alpha and two beta chains (possible).

6QS5
CRYSTAL STRUCTURE OF MAIZE CK2 IN COMPLEX WITH TYRPHOSTIN AG99
RCSB/PDB
Inspect Structure
See all 3D Structures for ACK2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
332P28523-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACK2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ACK2 there are:
41 structures (46 chains) solved
40 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ACK2 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (1DS5_A, 1DS5_B, 1DS5_C, 1DS5_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACK2 has been screened with 22 compounds (22 bioactivities), 17 compounds have bioactivities that show binding affinity of <= 500nM (17 bioactivities). (see details)