Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P28522) - Overview - Molecular Target Synopsis

Protein


, Ribosome-inactivating protein
Enzyme Classification 3.2.2.22
UniProt P28522

Also Known as RIPX_MAIZE

Potent catalytic inactivator of eukaryotic protein synthesis. It may be a component of natural defense mechanisms involved in protecting the kernel against soil-borne fungal infections. Synthesized and stored in the kernel as a 34 kDa inactive precursor. During germination, this neutral precursor is converted into a basic, active form by limited proteolysis, which removes 25 AA of net charge -6 from the center of the polypeptide chain. Additional processing also occurs at the N- and C-termini of the polypeptide. A two-chain active RIP (comprised of 16.5 and 8.5 kDa fragments that remain tightly associated) is produced from this processing event.

2K6H
NMR STRUCTURE OF AN UNUSUALLY 28 KDA ACTIVE MUTANT OF MAIZE RIBOSOME-INACTIVATING PROTEIN (MOD)
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
301P28522-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis