Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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secA (P28366) - Overview - Molecular Target Synopsis

Protein


secA, Protein translocase subunit SecA
UniProt P28366

Also Known as SECA_BACSU, secA, div+

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may be involved. Monomer and many different homodimers can be isolated (PubMed:16989859), some of which are not formed in the presence of a synthetic signal peptide. A single SecA monomer interacts with SecY in the channel.

6ITC
STRUCTURE OF A SUBSTRATE ENGAGED SECA-SECY PROTEIN TRANSLOCATION MACHINE
RCSB/PDB
Inspect Structure
See all 3D Structures for secA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
841P28366-1

Sub-cellular localization


UniProt: secA is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: secA is active in the following subcellular-locations: cell envelope Sec protein transport complex, cytosol, integral component of plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project secA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For secA there are:
11 structures (14 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis