Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXD10 (P28358) - Overview - Molecular Target Synopsis

Protein


HOXD10, Homeobox protein Hox-D10
UniProt P28358

Also Known as HXD10_HUMAN, HOXD10, HOX4D, HOX4E

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
340ENSG00000128710ENST00000249501ENSP00000249501P28358-1

Sub-cellular localization


UniProt: HOXD10 is active in the following subcellular-locations: nucleus.
GO terms: HOXD10 is active in the following subcellular-locations: cytoplasmic ribonucleoprotein granule, cytosol, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXD10 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, A498, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-ES-1, DMS 454, TC-71

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 75% identity similarity to HOXD10 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXD10 has been screened with compounds ( bioactivities). (see details)