Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXD9 (P28356) - Overview - Molecular Target Synopsis

Protein


HOXD9, Homeobox protein Hox-D9
UniProt P28356

Also Known as HXD9_HUMAN, HOXD9, HOX4C

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
352ENSG00000128709ENST00000249499ENSP00000249499P28356-1

Sub-cellular localization


UniProt: HOXD9 is active in the following subcellular-locations: nucleus.
GO terms: HOXD9 is active in the following subcellular-locations: nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXD9 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, IGROV1, RXF_393

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: VMRC-LCD, DMS 454, NCI-H810

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


At greater than 90% identity similarity to HOXD9 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXD9 has been screened with compounds ( bioactivities). (see details)