Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTM2 (P28161) - Overview - Molecular Target Synopsis

Protein


GSTM2, Glutathione S-transferase Mu 2
Enzyme Classification 2.5.1.18
UniProt P28161

Also Known as GSTM2_HUMAN, GSTM2, GST4

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Homodimer.

5HWL
HUMAN GLUTATHIONE S-TRANSFERASE MU2 COMPLEXED WITH BDEA, MONOCLINIC CRYSTAL FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTM2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTM2 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTM2 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, intercellular bridge, sarcoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTM2 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, MALME_3M, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-70, G122, AMO-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, IMR-90

(see details)

3D Structures


For GSTM2 there are:
11 structures (29 chains) solved
9 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

GSTM2 is solved in complex with the approved drug(s):

GDS/OXIGLUTATIONE (1YKC_A, 1YKC_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTM2 has been screened with 53 compounds (53 bioactivities), 34 compounds have bioactivities that show binding affinity of <= 500nM (34 bioactivities). (see details)