Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RPB9 (P27999) - Overview - Molecular Target Synopsis

Protein


RPB9, DNA-directed RNA polymerase II subunit RPB9
UniProt P27999

Also Known as RPB9_YEAST, RPB9

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation. Involved in DNA repair of damage in the transcribed strand. Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

6I84
STRUCTURE OF TRANSCRIBING RNA POLYMERASE II-NUCLEOSOME COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RPB9

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
122P27999-1

Sub-cellular localization


UniProt: RPB9 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RPB9 is active in the following subcellular-locations: nucleolus, RNA polymerase II.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPB9 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPB9 there are:
133 structures (135 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis