Molecular Target Synopsis
Overview
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Chemistry
Ligand Efficiency Plot
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cyaY (P27838) - Overview - Molecular Target Synopsis

Protein


cyaY, Iron-sulfur cluster assembly protein CyaY
UniProt P27838

Also Known as CYAY_ECOLI, cyaY

Involved in iron-sulfur (Fe-S) cluster assembly (PubMed:16603772, PubMed:19305405, PubMed:21799759, PubMed:25430730). May act as a regulator of Fe-S biogenesis (PubMed:19305405, PubMed:21799759, PubMed:25430730). Can bind both Fe(2+) and Fe(3+) ions (PubMed:15530368, PubMed:16603772, PubMed:17244611, PubMed:17651435). In vivo, has a positive effect on Fe-S cluster biogenesis under iron-rich growth conditions (PubMed:25430730). In vitro, can inhibit IscS cysteine desulfurase activity and the formation of Fe-S clusters on IscU (PubMed:19305405, PubMed:21799759). In vitro, in the presence of IscS and cysteine, Fe(3+)-CyaY can be used as an iron donor during Fe-S cluster assembly on the scaffold protein IscU (PubMed:16603772). Monomer (PubMed:16603772, PubMed:19305405, PubMed:28931050). Forms homodimers and higher oligomers in the presence of iron (PubMed:16603772, PubMed:28931050). Interacts with IscS (PubMed:16603772, PubMed:19305405, PubMed:25430730).

2EFF
CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX BETWEEN CYAY AND CO(II)
RCSB/PDB
Inspect Structure
See all 3D Structures for cyaY

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: cyaY is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project cyaY has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For cyaY there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis