Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP4 (P27485) - Overview - Molecular Target Synopsis

Protein


RBP4, Retinol-binding protein 4
UniProt P27485

Also Known as RET4_PIG, RBP4

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.

1AQB
RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA
RCSB/PDB
Inspect Structure
See all 3D Structures for RBP4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
201P27485-1

Sub-cellular localization


UniProt: RBP4 is active in the following subcellular-locations: secreted.
GO terms: RBP4 is active in the following subcellular-locations: extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RBP4 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RBP4 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RBP4 is solved in complex with the approved drug(s):

RTL/RETINOL (1AQB_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RBP4 has been screened with compounds ( bioactivities). (see details)