Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAOB (P27338) - Overview - Molecular Target Synopsis

Protein


MAOB, Amine oxidase [flavin-containing] B
Enzyme Classification 1.4.3.4
UniProt P27338

Also Known as AOFB_HUMAN, MAOB

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

6FVZ
CRYSTAL STRUCTURE OF HUMAN MONOAMINE OXIDASE B (MAO B) IN COMPLEX WITH DIMETHYLPHENYL-CHROMONE-CARBOXAMIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for MAOB

Isoforms / Transcripts (Protein Coding)


Drugs


MAOB is targeted by Approved Drugs Chlorphentermine, Phentermine, Safinamide, Phenelzine, Selegiline. (see details)
Chlorphentermine
Phentermine
Safinamide
Phenelzine
Selegiline

Sub-cellular localization


UniProt: MAOB is active in the following subcellular-locations: mitochondrion outer membrane.
GO terms: MAOB is active in the following subcellular-locations: integral component of membrane, mitochondrial envelope, mitochondrial outer membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAOB has gain in 1 cell-lines, loss in 65 cell-lines and no signal in 939 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, HCT_116, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JHH-2, NCI-H2073, CL-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, HSMM

(see details)

3D Structures


For MAOB there are:
43 structures (94 chains) solved
43 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

MAOB is solved in complex with the approved drug(s):

ZON/ZONISAMIDE (3PO7_A, 3PO7_B),
MBT/METHYLENE BLUE (3ZYX_A, 3ZYX_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAOB has been screened with 4420 compounds (6651 bioactivities), 1164 compounds have bioactivities that show binding affinity of <= 500nM (1535 bioactivities). (see details)