Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

folK (P26281) - Overview - Molecular Target Synopsis

Protein


folK, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Enzyme Classification 2.7.6.3
UniProt P26281

Also Known as HPPK_ECOLI, folK

Monomer.

6AN6
CRYSTAL STRUCTURE OF ESCHERICHIA COLI HPPK IN COMPLEX WITH BISUBSTRATE ANALOGUE INHIBITOR HP-72
RCSB/PDB
Inspect Structure
See all 3D Structures for folK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
159P26281-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project folK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For folK there are:
56 structures (65 chains) solved
42 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

folK is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (1RAO_A),
DX4/THIOGUANINE (4M5M_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


folK has been screened with 74 compounds (110 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)