Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Tln1 (P26039) - Overview - Molecular Target Synopsis

Protein


Tln1, Talin-1
UniProt P26039

Also Known as TLN1_MOUSE, Tln1, Tln

Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Interacts with NRAP and LAYN (By similarity). Interacts with SYNM (By similarity). Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1 (By similarity). Binds with high affinity to VCL and with low affinity to integrins (PubMed:23389036, PubMed:20610383, PubMed:15642262, PubMed:15272303). Interacts with APBB1IP; this inhibits VCL binding (PubMed:23389036). Interacts with PTK2/FAK1 (PubMed:7622520). Interacts with PIP5K1C (PubMed:15623515). Interacts with F-actin (PubMed:20610383).

6MFS
MOUSE TALIN1 RESIDUES 1-138 FUSED TO RESIDUES 169-400 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2)
RCSB/PDB
Inspect Structure
See all 3D Structures for Tln1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
2541P26039-1

Sub-cellular localization


UniProt: Tln1 is active in the following subcellular-locations: cell junction, cell projection, cell surface, cytoplasm, cytoskeleton, focal adhesion, ruffle membrane.
GO terms: Tln1 is active in the following subcellular-locations: cell surface, cytoplasm, cytoskeleton, focal adhesion, ruffle, ruffle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Tln1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Tln1 there are:
32 structures (49 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Tln1 has been screened with compounds ( bioactivities). (see details)