Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CTSS (P25774) - Overview - Molecular Target Synopsis

Protein


CTSS, Cathepsin S
Enzyme Classification 3.4.22.27
UniProt P25774

Also Known as CATS_HUMAN, CTSS

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. Monomer.

5QBU
CRYSTAL STRUCTURE OF HUMAN CATHEPSIN-S WITH BOUND LIGAND
RCSB/PDB
Inspect Structure
See all 3D Structures for CTSS

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project CTSS has gain in 22 cell-lines, loss in 0 cell-lines and no signal in 983 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, SF_295, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MOLP-2, Hs 746T, A4/Fuk

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, CD20-positive B cell, SK-N-SH

(see details)

3D Structures


For CTSS there are:
54 structures (103 chains) solved
52 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CTSS has been screened with 2733 compounds (3672 bioactivities), 1680 compounds have bioactivities that show binding affinity of <= 500nM (2192 bioactivities). (see details)