Molecular Target Synopsis
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DNAJB1 (P25685) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed12
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria11


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3AGZ_B DnaJ homolog subfamily B member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 61.3 34.7 Yes No
2 empty 2.47 68.8 19.2 No No
3 empty 1.89 70.9 9.6 No No
4 empty 2.18 56.6 16.9 No No
5 empty 2.15 60.1 18.8 No No
6 empty 2.59 57.7 12.7 No No
7 empty 1.94 65.9 10.2 No No
8 empty 2.44 68.8 6.7 No No
9 empty 2.36 58.5 8.5 No No
10 empty 2.62 44.8 9.1 No No
3AGY_A DnaJ homolog subfamily B member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 58.6 26.3 Yes No
2 empty 2 61.5 20.3 No No
3 empty 2.17 63.5 21.5 No No
4 empty 2.22 62.5 16.8 No No
5 empty 2.38 65.4 13.2 No No
6 empty 2.51 49.7 13.4 No No
7 empty 2.18 50.7 13.5 No No
8 empty 2.51 57.6 13.4 No No
9 empty 2.63 62.3 11.4 No No
10 empty 2.55 67.3 7.6 No No
6BYR_A DnaJ homolog subfamily B member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 70.3 39.9 Yes Yes
2 bound 1.93 70.3 39.1 No No
3 empty 2.64 66.8 27.1 No No
4 empty 2.78 68.1 15.9 No No
5 empty 2.11 65.9 25.2 No No
6 empty 2.11 59.7 21.7 No No
7 empty 2.56 61.7 22.9 No No
8 empty 2.03 74.4 17.8 No No
9 empty 2.14 68.9 13.4 No No
10 empty 1.83 68.8 13.7 No No
3AGX_B DnaJ homolog subfamily B member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.25 58.6 24.7 Yes No
2 empty 2.53 61.5 25.7 No No
3 empty 1.94 55.1 16.8 No No
4 empty 2.07 58.1 15.9 No No
5 empty 2.48 51.4 14.9 No No
6 empty 2.64 67.8 7.3 No No
7 empty 2.76 67.3 6.6 No No
8 empty 2.54 57.7 9.5 No No
9 empty 2.58 54.7 10.2 No No
10 empty 1.86 69.9 9.4 No No
4WB7_A DnaJ homolog subfamily B member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 72.4 44.7 Yes Yes
2 bound 1.93 71 38.9 No No
3 empty 2.37 69.4 29.6 No No
4 empty 2.57 70.3 17.3 No No
5 empty 2.25 62.5 21.4 No No
6 empty 2.31 65.4 21.3 No No
7 empty 2.23 77.5 11.4 No No
8 empty 2.29 69 13.8 No No
9 empty 1.92 64.2 13.1 No No
10 empty 2.5 58.2 18 No No
3AGY_B DnaJ homolog subfamily B member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.22 59.2 25.4 Yes No
2 empty 2.48 65 27.9 No No
3 empty 1.84 61.8 19.8 No No
4 empty 1.77 60.6 17.2 No No
5 empty 2.26 53.6 14.1 No No
6 empty 2.44 50 12.5 No No
7 empty 2.29 53.6 16.1 No No
8 empty 2.55 64.9 10.2 No No
9 empty 2.79 66.7 10 No No
10 empty 2.51 60.1 10.2 No No
4WB7_B DnaJ homolog subfamily B member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 69.7 41.1 Yes Yes
2 bound 2.06 72.6 35.8 No No
3 empty 2.28 67.8 32.7 No No
4 empty 2.7 70.5 16.3 No No
5 empty 2.17 61.3 22.5 No No
6 empty 2.33 64.9 14.8 No No
7 empty 2.31 66.4 15.1 No No
8 empty 2.23 77.7 14.6 No No
9 empty 2.21 74.4 11.8 No No
10 empty 2.54 58.3 15 No No
2QLD_A DnaJ homolog subfamily B member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 53.6 19 No No
2 empty 2.36 64.5 34.2 No No
3 empty 2.09 65.4 22.9 No No
4 empty 1.71 64.1 12.1 No No
5 empty 1.83 57.5 12.2 No No
6 empty 2.27 59.8 12.4 No No
7 empty 1.93 49 9.7 No No
8 empty 2.52 59.5 10.1 No No
9 empty 2.82 69.5 12.1 No No
10 empty 2.06 73.9 10.1 No No
6BYR_C DnaJ homolog subfamily B member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 67.9 41.5 Yes Yes
2 bound 1.94 71.6 36.4 No No
3 empty 2.31 70.4 27 No No
4 empty 2.59 64.3 22.5 No No
5 empty 2.55 63.7 21.4 No No
6 empty 2.06 66.3 17.1 No No
7 empty 2.22 59.9 17.8 No No
8 empty 2.25 62.2 14.9 No No
9 empty 2.05 62.1 13.6 No No
10 empty 2.24 75.6 10.3 No No
1HDJ_A DnaJ homolog subfamily B member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 60.3 26.7 Yes No
2 empty 2.81 61.7 12.7 No No
3 empty 2.84 65.1 11.4 No No
4 empty 2.62 65.3 10.5 No No
5 empty 2.48 69.8 9.3 No No
6 empty 2.79 64.8 8.8 No No
7 empty 2.21 70 14 No No
8 empty 2.65 54.2 9 No No
9 empty 2.63 67.2 6.3 No No
10 empty 3.07 46.7 7.5 No No
3AGX_A DnaJ homolog subfamily B member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.35 58.3 25.7 Yes No
2 empty 2.12 62.1 23 No No
3 empty 2.43 58.1 21.1 No No
4 empty 2.2 62.6 12.9 No No
5 empty 2 49.5 11.3 No No
6 empty 2.4 58.7 14 No No
7 empty 2.25 66 10.1 No No
8 empty 2.6 66.7 10.8 No No
9 empty 2.55 58.2 9.1 No No
10 empty 2.72 69.8 9.2 No No
3AGZ_A DnaJ homolog subfamily B member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.25 56.3 29.2 Yes No
2 empty 2.45 63 33.7 No No
3 empty 2.18 61.3 21.6 No No
4 empty 2.1 64.8 21.3 No No
5 empty 2.61 53.4 16 No No
6 empty 2.25 56.1 12.3 No No
7 empty 2.28 61.5 14.3 No No
8 empty 2.48 60.4 9.3 No No
9 empty 1.94 65.5 8.9 No No
10 empty 2 51.5 10.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed10
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria5

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1HDJ_A (15696) DnaJ homolog subfamily B member 1 Long alpha-hairpin, Chaperone J-domain, Chaperone J-domain Yes No
2QLD_A (3190333) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 2.7Å No No
2QLD_A (3190334) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 2.7Å No No
3AGX_A (3610129) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 1.85Å Yes No
3AGX_B (4268631) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain (Homo Multimer) 1.85Å Yes Yes
3AGX_A (4268631) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain (Homo Multimer) 1.85Å Yes Yes
3AGX_A (3610128) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 1.85Å No No
3AGY_A (3610130) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 1.85Å No No
3AGY_A (3610131) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 1.85Å Yes No
3AGZ_A (3610133) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 2.51Å Yes No
3AGZ_A (3610132) DnaJ homolog subfamily B member 1 HSP40/DnaJ peptide-binding domain, HSP40/DnaJ peptide-binding domain, UNMATCHED 2.51Å No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


DNAJB1 is involved in 30 interactions in the network.


Druggability
Overall Druggability Percentile: 74.51
Druggability for Cancer Therapeutics: 88.85
Druggability for Other Therapeutics: 50.84
Cancer-Associated
Cancer-associated percentile : 86.58
Network Articulation Point
Is DNAJB1 critical for communication in the network?


Detailed Graph Legend:Help