DNAJB1 (P25685) - Overview - Molecular Target Synopsis
DNAJB1, DnaJ homolog subfamily B member 1
Also Known as DNJB1_HUMAN, DNAJB1, DNAJ1, HDJ1, HSPF1
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). Interacts with DNAJC3 (PubMed:9920933). Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: DNAJB1 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleus.
GO terms: DNAJB1 is active in the following subcellular-locations: cytoplasm, cytosol, dendritic spine, extracellular exosome, glutamatergic synapse, neuronal cell body, nucleolus, nucleoplasm, nucleus, postsynaptic density, sperm head.