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RPC53 (P25441) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed15
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria15


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6CNF_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 63.7 38.3 Yes No
2 empty 2.28 61.2 37.8 No No
3 empty 1.73 72.6 22.4 No No
4 empty 2.21 63.3 11.2 No No
5 empty 2.09 58.5 11.7 No No
6 empty 2.78 68.4 11.6 No No
7 empty 2.31 53.9 10 No No
8 empty 2.06 64.4 6.7 No No
9 empty 2.15 59.2 10.3 No No
10 empty 2.82 73 8.4 No No
5FJA_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 63.7 42.1 Yes No
2 empty 1.54 74.1 21 Yes No
3 empty 2.55 54.9 17.4 No No
4 empty 2.18 65.9 11.6 No No
5 empty 2.33 64.9 12.6 No No
6 empty 2.33 61.1 14.1 No No
7 empty 1.81 57.7 15.2 No No
8 empty 1.47 60.9 13.2 No No
9 empty 2.8 59.6 8.9 No No
10 empty 1.94 44.5 9.5 No No
5FJ9_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 63.4 42.3 Yes No
2 empty 1.65 70.5 23.2 No No
3 empty 2.08 63.9 20.2 No No
4 empty 2.32 64.1 13.2 No No
5 empty 2.36 62.1 13.8 No No
6 empty 1.97 47.3 8.2 No No
7 empty 2.22 49.3 7.3 No No
8 empty 2.58 72.9 6.4 No No
9 empty 2.46 53.3 6.1 No No
10 empty .49 90.9 0 Yes No
6EU2_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 64.6 38.4 Yes No
2 empty 2.12 67.9 15.4 No No
3 empty 1.4 78.2 10 No No
4 empty 1.91 77.3 13.4 No No
5 empty 2.33 67.3 13.5 No No
6 empty 1.44 64.4 9.2 No No
7 empty 2.36 60.5 13 No No
8 empty 2.52 53 14.3 No No
9 empty 1.37 53.4 8.7 No No
10 empty 2.17 69.2 7.4 No No
5FJ8_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 64.1 42.4 Yes No
2 empty 1.67 73.4 23.8 Yes No
3 empty 2.22 65.7 26.5 No No
4 empty 2.41 56.9 14.7 No No
5 empty 2.44 61.3 13.7 No No
6 empty 1.78 51.3 17.1 No No
7 empty 2.81 67.1 7.6 No No
8 empty 1.95 48.8 9.5 No No
9 empty 2.39 56.1 8 No No
10 empty 2.64 71.4 0 No No
6F42_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 64.9 24.4 Yes No
2 empty 2.26 65.6 20.4 No No
3 empty 1.66 62.5 22.3 No No
4 empty 1.52 70.2 23.3 No No
5 empty 1.89 60.4 22.1 No No
6 empty 2.31 57.1 8.1 No No
7 empty 2.56 58.8 10.7 No No
8 empty 2.54 57.2 8.2 No No
9 empty 3.01 60.6 7.6 No No
10 empty 1.9 91.6 2.9 Yes No
6EU1_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 65.3 43.4 Yes No
2 empty 1.82 73.4 16.1 No No
3 empty 2.1 69.5 16.2 No No
4 empty 2.34 64.2 14.3 No No
5 empty 2.3 64.5 7.5 No No
6 empty 2.31 49.7 10.6 No No
7 empty .62 83.1 8.4 No No
8 empty 2.7 71.9 6.6 No No
9 empty 2.95 94.8 0 Yes No
10 empty 2.18 61.8 8.8 No No
6CNC_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 62.5 26 Yes No
2 empty 2.37 62.4 34.6 No No
3 empty 1.45 76.9 14.4 No No
4 empty 2.08 65.5 13.8 No No
5 empty 2.12 58.9 11.3 No No
6 empty 2.18 61.7 14.4 No No
7 empty 2.61 78.4 10 No No
8 empty 1.66 64.5 11.1 No No
9 empty 2.81 62.6 9.2 No No
10 empty .57 99.2 0 Yes No
6F41_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 66 24.1 Yes No
2 empty 2.55 67.8 20.4 No No
3 empty 1.59 62.6 27.1 No No
4 empty 1.37 76.2 17 No No
5 empty 1.87 60 19 No No
6 empty 2.63 66.7 10 No No
7 empty 2.18 71.8 7.3 No No
8 empty 2.62 55.9 11.4 No No
9 empty 1.96 69.5 5.6 No No
10 empty 1.53 95.7 0 Yes No
6EU3_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 64.2 36.8 Yes No
2 empty 1.77 71.5 23.2 No No
3 empty 1.31 63.4 13 No No
4 empty 1.9 73.8 8.2 No No
5 empty 2.51 65.3 12.5 No No
6 empty 1.83 55.5 12.5 No No
7 empty 2.04 50 10 No No
8 empty 2.36 49.2 9 No No
9 empty 2.01 73.9 0 No No
10 empty 2.08 59.9 8.2 No No
6F40_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 65.4 24.5 Yes No
2 empty 2.18 64.4 21 No No
3 empty 1.76 61.5 21.9 No No
4 empty 1.64 76 17.3 No No
5 empty 1.99 60.5 20.7 No No
6 empty 2.15 65.7 9.8 No No
7 empty 2.3 56.4 7.5 No No
8 empty 2.56 59.3 6.5 No No
9 empty 2.84 59.5 7.6 No No
10 empty 2.22 80.4 7 No No
6F44_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 62 39.6 Yes No
2 empty 1.52 68 38.1 No No
3 empty 2.4 58.9 10.6 No No
4 empty 2.59 58.1 9.2 No No
5 empty 2.72 63.6 7.9 No No
6 empty 2.35 56 7.4 No No
7 empty 2 76.9 7.7 No No
8 empty 1.28 98.4 0 Yes No
9 empty 2.17 51.9 6.2 No No
10 empty 1.98 100 0 Yes No
6EU0_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 64.1 39.2 Yes No
2 empty 1.44 68.4 32.3 No No
3 empty 2.2 59.9 13.5 No No
4 empty 1.74 73.3 9.4 No No
5 empty 2.05 62.3 9.8 No No
6 empty 2.18 56.3 10.2 No No
7 empty 3 53.7 10 No No
8 empty 1.84 51.9 9.7 No No
9 empty 2.93 66.4 8 No No
10 empty 1.92 64.3 6.1 No No
6CNB_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 63.8 36.6 Yes No
2 empty 2.33 62.7 33.1 No No
3 empty 1.51 81.1 16.4 No No
4 empty 2.44 52.7 11.2 No No
5 empty 2.29 61.1 13.4 No No
6 empty 2.09 63.2 11.8 No No
7 empty 2.44 58.7 10.4 No No
8 empty 1.98 65.3 8.9 No No
9 empty 2.19 49.3 9 No No
10 empty 2.33 62.5 6.8 No No
6CND_N DNA-directed RNA polymerase III subunit RPC4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 65.7 32.8 Yes No
2 empty 2.11 70.6 33.6 No No
3 empty 1.98 64.1 12.9 No No
4 empty 2.04 62.5 11.1 No No
5 empty 2.55 56.1 11 No No
6 empty 2.03 62.4 10.3 No No
7 empty 2.65 74.1 9 No No
8 empty 2.8 55.7 10.8 No No
9 empty 2.06 54.1 10 No No
10 empty 2.56 45.7 9.1 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score