Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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RPC53 (P25441) - Overview - Molecular Target Synopsis

Protein


RPC53, DNA-directed RNA polymerase III subunit RPC4
UniProt P25441

Also Known as RPC4_YEAST, RPC53, RPC4

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC37/RPC5. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.

6CNF
YEAST RNA POLYMERASE III ELONGATION COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RPC53

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
422P25441-1

Sub-cellular localization


UniProt: RPC53 is active in the following subcellular-locations: nucleus.
GO terms: RPC53 is active in the following subcellular-locations: nucleoplasm, RNA polymerase III complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPC53 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPC53 there are:
15 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis