Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MPST (P25325) - Overview - Molecular Target Synopsis

Protein


MPST, 3-mercaptopyruvate sulfurtransferase
Enzyme Classification 2.8.1.2
UniProt P25325

Also Known as THTM_HUMAN, MPST, TST2

Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. Monomer (active form). Homodimer; disulfide-linked (inactive form).

4JGT
STRUCTURE AND KINETIC ANALYSIS OF H2S PRODUCTION BY HUMAN MERCAPTOPYRUVATE SULFURTRANSFERASE
RCSB/PDB
Inspect Structure
See all 3D Structures for MPST

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MPST is active in the following subcellular-locations: cell junction, cytoplasm, mitochondrion, synapse, synaptosome.
GO terms: MPST is active in the following subcellular-locations: cell junction, cytosol, extracellular exosome, mitochondrial matrix, neuron projection, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MPST has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, KM12, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 206F, COLO 205, JHH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, K562

(see details)

3D Structures


For MPST there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis