Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LTF (P24627) - Overview - Molecular Target Synopsis

Protein


LTF, Lactotransferrin
Enzyme Classification 3.4.21.-
UniProt P24627

Also Known as TRFL_BOVIN, LTF

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate., Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity. Antimicrobial properties may include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. The most effective inhibitory activity is seen against E.coli and P.aeruginosa. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Interferes with the lipopolysaccharide (LPS)-stimulated TLR4 signaling, but cannot directly stimulate the TLR4 signaling pathway and subsequent NF-kappa-B activation., Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria., The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. Monomer. Found in a complex with LTF, CLU, EPPIN and SEMG1 (By similarity).

5HBC
INTERMEDIATE STRUCTURE OF IRON-SATURATED C-LOBE OF BOVINE LACTOFERRIN AT 2.79 ANGSTROM RESOLUTION INDICATES THE SOFTENING OF IRON COORDINATION
RCSB/PDB
Inspect Structure
See all 3D Structures for LTF

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
708P24627-1

Sub-cellular localization


UniProt: LTF is active in the following subcellular-locations: cytoplasmic granule, secreted.
GO terms: LTF is active in the following subcellular-locations: cell surface, extracellular space, other organism cell membrane, protein-containing complex, specific granule.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LTF has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For LTF there are:
82 structures (102 chains) solved
76 are solved in complex with at least one small molecule ligand
24 are solved with an approved drug

LTF is solved in complex with the approved drug(s):

IMN/INDOMETHACIN (3IB1_A),
IBP/DEXIBUPROFEN (3IB2_A),
TLF/TOLFENAMIC ACID (4G77_A),
SUC/SUCROSE (2DVC_A),
FRU/FRUCTOSE (2DWJ_A, 2O51_A),
NBO/NABUMETONE (3TAJ_A),
BGC/DEXTROSE (2ZMB_A),
PXB/PARECOXIB (2ZMB_A),
ID8/MEFENAMIC ACID (4G2Z_A),
5CH/ETORICOXIB (3CFL_A),
DIF/DICLOFENAC (3IB0_A),
ACA/AMINOCAPROIC ACID (4DXU_A),
TYL/ACETAMINOPHEN (2OCU_A),
NIO/NIACIN (3CI8_A),
NCA/NIACINAMIDE (2R9J_A),
CEL/CELECOXIB (4FIM_A),
SOR/SORBITOL (2DXR_A),
COU/COUMARIN (3CRB_A),
JMS/MECLOFENAMIC ACID (4N6P_A),
NIM/NIMESULIDE (3E9X_A),
ADN/ADENOSINE (2DOJ_A),
LQZ/LIDOCAINE (3TTR_A),
NPS/NAPROXEN (4FJP_A),
AIN/ASPIRIN (3IAZ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LTF has been screened with 7 compounds (7 bioactivities). (see details)