Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

xylA (P24300) - Overview - Molecular Target Synopsis

Protein


xylA, Xylose isomerase
Enzyme Classification 5.3.1.5
UniProt P24300

Also Known as XYLA_STRRU, xylA

Involved in D-xylose catabolism. Homotetramer.

6QUK
PROTEIN CRYSTALLIZATION BY IONIC LIQUID HYDROGEL SUPPORT: GLUCOSE ISOMERASE GROWN BY USING IONIC LIQUID HYDROGEL
RCSB/PDB
Inspect Structure
See all 3D Structures for xylA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
388P24300-1

Sub-cellular localization


UniProt: xylA is active in the following subcellular-locations: cytoplasm.
GO terms: xylA is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project xylA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For xylA there are:
71 structures (79 chains) solved
41 are solved in complex with at least one small molecule ligand
6 are solved with an approved drug

xylA is solved in complex with the approved drug(s):

SOR/SORBITOL (1XIH_A, 4DVO_A),
FRU/FRUCTOSE (4ZB0_A, 4ZB0_B, 4ZB2_A, 4ZBC_A, 4ZBC_B),
ASC/ASCORBIC ACID (1XID_A).

(see details)
Molecular Target 3D Synopsis