Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Slc6a3 (P23977) - Overview - Molecular Target Synopsis

Protein


Slc6a3, Sodium-dependent dopamine transporter
UniProt P23977

Also Known as SC6A3_RAT, Slc6a3

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Homooligomer; disulfide-linked (By similarity). Interacts with PRKCABP and TGFB1I1. Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2. Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity). Interacts with alpha-synuclein/SNCA.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
619P23977-1

Sub-cellular localization


UniProt: Slc6a3 is active in the following subcellular-locations: cell membrane.
GO terms: Slc6a3 is active in the following subcellular-locations: axon, cell surface, dopaminergic synapse, flotillin complex, integral component of postsynaptic membrane, integral component of presynaptic membrane, neuron projection, neuronal cell body, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Slc6a3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Slc6a3 has been screened with 3451 compounds (7894 bioactivities), 2080 compounds have bioactivities that show binding affinity of <= 500nM (3572 bioactivities). (see details)