Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Gata3 (P23772) - Overview - Molecular Target Synopsis

Protein


Gata3, Trans-acting T-cell-specific transcription factor GATA-3
UniProt P23772

Also Known as GATA3_MOUSE, Gata3, Gata-3

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Interacts with TBX21 ('Tyr-525' phosphorylated form).

3DFV
ADJACENT GATA DNA BINDING
RCSB/PDB
Inspect Structure
See all 3D Structures for Gata3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
443P23772-1

Sub-cellular localization


UniProt: Gata3 is active in the following subcellular-locations: nucleus.
GO terms: Gata3 is active in the following subcellular-locations: nuclear chromatin, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Gata3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Gata3 there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Gata3 has been screened with compounds ( bioactivities). (see details)