Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rbcL (P23755) - Overview - Molecular Target Synopsis

Protein


rbcL, Ribulose bisphosphate carboxylase large chain
Enzyme Classification 4.1.1.39
UniProt P23755

Also Known as RBL_GALSU, rbcL

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Heterohexadecamer of 8 large chains and 8 small chains.

4F0H
UNACTIVATED RUBISCO WITH OXYGEN BOUND
RCSB/PDB
Inspect Structure
See all 3D Structures for rbcL

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
493P23755-1

Sub-cellular localization


UniProt: rbcL is active in the following subcellular-locations: chloroplast, plastid.
GO terms: rbcL is active in the following subcellular-locations: chloroplast.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rbcL has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rbcL there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis