Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
RNAi
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Germline Genetics

PREP (P23687) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed28
Chains with at least one site assessed as druggable using the strict criteria28
Chains with at least one site assessed as druggable using the relaxed criteria28


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3EQ9_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 76.2 61.7 Yes Yes
2 empty 2.62 67.2 36.3 No No
3 empty 2.11 69.3 41.6 No No
4 empty 1.81 69.4 35.4 No No
5 empty 2.07 70.5 19 No No
6 empty 2.53 68.4 28.7 No No
7 empty 1.99 62.7 17.9 No No
8 empty 2.07 67.8 22.5 No No
9 empty 1.94 66.6 20.5 No No
10 empty 1.94 69.9 16.9 No No
1VZ3_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 78.5 28.7 Yes Yes
2 bound 2.3 63 29.7 No No
3 empty 1.8 72.8 20.7 No No
4 empty 2.02 60.5 26.2 No No
5 empty 2.04 74.6 14.7 No No
6 empty 2.44 61.5 21.5 No No
7 empty 1.84 61.3 24.6 No No
8 empty 2.01 59.2 18 No No
9 empty 1.51 66.7 19.5 No No
10 empty 2.2 58.3 21.5 No No
1O6F_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 80.9 29.9 Yes Yes
2 bound 2.4 61.5 30 No No
3 empty 1.8 64.3 28 No No
4 empty 2.05 63.4 23.6 No No
5 bound 1.98 77.7 16.3 No No
6 empty 1.73 64.2 34.9 No No
7 empty 2.66 65.4 21.1 No No
8 empty 2.22 55.8 29.9 No No
9 empty 1.91 72.9 14.1 No No
10 empty 1.95 60.8 19 No No
3EQ7_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 76.7 59.6 Yes Yes
2 empty 2.43 66.8 33.5 No No
3 empty 2.08 70.4 19.2 No No
4 empty 1.93 69.3 34.9 No No
5 empty 2.31 70.5 17.1 No No
6 empty 1.7 67.9 18.8 No No
7 empty 2.23 66 17.8 No No
8 empty 2.24 67.7 22.8 No No
9 empty 1.8 64.7 13.5 No No
10 empty 2.1 65.1 19.4 No No
4AN0_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 78.5 29.6 Yes Yes
2 bound 2.37 61.6 32.1 No No
3 empty 2.09 60.6 28.5 No No
4 empty 1.7 66.1 25.5 No No
5 empty 1.73 62.7 37.4 No No
6 bound 2.07 77.6 17.7 No No
7 empty 2.43 66.1 21.3 No No
8 empty 2.19 60.1 19.8 No No
9 empty 1.9 70.6 13.9 No No
10 empty 2.29 52.1 17 No No
1UOP_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 81.5 28.6 Yes Yes
2 bound 2.3 61.8 30.6 No No
3 empty 2.44 55.7 29.1 No No
4 empty 1.86 63.8 25.7 No No
5 empty 1.95 62.4 22.1 No No
6 bound 1.96 79.3 13.7 No No
7 empty 2.57 64.8 19.1 No No
8 empty 1.93 68.6 16.2 No No
9 empty 1.67 60.7 19.6 No No
10 empty 1.78 60.2 14.5 No No
1E8N_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 80.1 28.8 Yes Yes
2 bound 2.21 63.2 27.2 No No
3 empty 2.02 78 22.1 No No
4 bound 2.02 76.2 15 No No
5 empty 1.93 62.7 24.5 No No
6 empty 2.39 55.8 26.5 No No
7 empty 2.4 66.1 19.3 No No
8 empty 1.84 63.7 19.4 No No
9 empty 1.91 67 16.5 No No
10 empty 1.94 60.1 16.3 No No
4AMZ_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 79.1 29.3 Yes Yes
2 bound 2.33 62.8 31.2 No No
3 empty 1.82 65.1 23.2 No No
4 empty 2.02 63 23.7 No No
5 empty 1.84 75.2 19.3 No No
6 bound 2.13 79.7 14.6 No No
7 empty 2.53 61.7 20.2 No No
8 empty 1.98 66.4 27.9 No No
9 empty 2.51 52.9 26.3 No No
10 empty 2.02 66 19.3 No No
1UOQ_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 79.9 33.8 Yes Yes
2 empty 2.33 63.6 25 No No
3 empty 2.05 64.3 25.8 No No
4 empty 2.02 63.1 27 No No
5 empty 1.69 66.8 25.3 No No
6 empty 1.81 72.6 19.6 No No
7 empty 2.39 55.2 24.6 No No
8 empty 2.63 68.8 23.3 No No
9 empty 1.89 67 16 No No
10 empty 1.84 68.3 15.9 No No
4BCB_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 78.4 28.8 Yes Yes
2 bound 2.37 61 27.4 No No
3 empty 1.86 66.6 25.1 No No
4 bound 2.06 79 15.3 No No
5 empty 2.39 57.6 32.2 No No
6 empty 2.48 61.7 21.8 No No
7 empty 1.96 67.4 21 No No
8 empty 1.96 61.1 23.6 No No
9 empty 2.3 65 19 No No
10 bound 1.75 68.7 18.3 No No
2XDW_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 77.9 30 Yes Yes
2 bound 2.35 60.9 30.7 No No
3 empty 1.85 66.7 26.1 No No
4 bound 2.05 77.9 14.3 No No
5 empty 1.97 60.3 22.9 No No
6 empty 2.46 55.6 27.1 No No
7 empty 2.49 63 22.1 No No
8 empty 2.06 67.5 21.1 No No
9 bound 1.68 71.3 13.4 No No
10 empty 1.79 60.6 20.7 No No
1O6G_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 74.3 66.7 Yes Yes
2 empty 2.41 68 29.1 No No
3 empty 1.77 66.4 28.3 No No
4 empty 2.04 68.1 24.9 No No
5 empty 1.68 69.1 36.6 No No
6 empty 2.44 64.3 23.1 No No
7 empty 2.21 65.1 25.3 No No
8 empty 2.34 62.3 34.2 No No
9 empty 1.76 66.3 19.5 No No
10 empty 2.23 62.9 19.1 No No
1VZ2_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 82.3 30.5 Yes Yes
2 bound 2.29 62.8 41.3 No No
3 empty 1.98 80.9 18.3 No No
4 empty 2.45 55.4 28.2 No No
5 empty 1.79 65.8 25.4 No No
6 empty 2.4 66.2 19.8 No No
7 empty 2.02 62.4 22.5 No No
8 empty 1.94 68.3 16.6 No No
9 empty 2.36 61.1 22.7 No No
10 empty 2.17 61.1 17.9 No No
4BCD_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 78.3 29.8 Yes Yes
2 bound 2.3 60.6 34.1 No No
3 empty 1.87 66.1 23.5 No No
4 empty 1.97 63 23.1 No No
5 empty 2.51 58.5 31 No No
6 empty 2.09 63.6 25.3 No No
7 bound 2.11 76 14.5 No No
8 bound 1.83 72.2 19.4 No No
9 empty 2.43 62.5 20 No No
10 empty 1.92 57.8 17.4 No No
1H2Z_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 79.8 31.9 Yes Yes
2 empty 1.9 65.4 37.5 No No
3 empty 2 62.7 25.5 No No
4 empty 1.84 64.4 27 No No
5 empty 2.15 62.9 25.6 No No
6 empty 1.82 74.4 20.2 No No
7 empty 2.39 55.8 25.5 No No
8 empty 2.35 69.4 17.1 No No
9 empty 2.48 61.1 25.1 No No
10 empty 1.67 67 19 No No
1H2X_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 78.4 28.8 Yes Yes
2 empty 1.77 67.5 24.8 No No
3 bound 2.32 62 27.8 No No
4 empty 1.97 64.1 25.8 No No
5 empty 2.41 58.1 28.9 No No
6 bound 2.04 79.7 16.1 No No
7 empty 1.86 73.3 20.1 No No
8 empty 2.49 63.9 21.6 No No
9 empty 1.85 64.1 19.3 No No
10 empty 1.87 70 13.1 No No
1E8M_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 79.4 47.5 Yes Yes
2 empty 2.69 67.4 54 No No
3 empty 2.34 65 35.2 No No
4 empty 1.91 68 34.3 No No
5 empty 2.06 71.5 34.6 No No
6 empty 1.83 68.9 35.8 No No
7 empty 2.09 69.5 22.3 No No
8 empty 2.37 60.8 28.8 No No
9 empty 2.4 60.9 36.1 No No
10 empty 1.75 69.4 18.3 No No
1UOO_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 80.5 47 Yes Yes
2 empty 2.25 67.5 34.9 No No
3 empty 2.07 68.6 21.4 No No
4 empty 2.02 69.2 30.7 No No
5 empty 2.37 61.5 30.8 No No
6 empty 1.79 67.9 19.9 No No
7 empty 2.1 73.8 28.8 No No
8 empty 2.06 64.2 30.3 No No
9 empty 2.52 67.7 25 No No
10 empty 2.42 64.7 24.5 No No
1H2Y_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 78.5 29.1 Yes Yes
2 bound 2.38 60.9 33.8 No No
3 empty 1.92 66.5 22.9 No No
4 empty 2.5 61.7 23.7 No No
5 empty 2.52 59.4 27 No No
6 bound 2.02 78.1 17 No No
7 empty 1.94 60.9 24.6 No No
8 empty 1.98 66.2 29.5 No No
9 empty 1.92 71.1 19.4 No No
10 empty 1.77 67.7 19.6 No No
4AX4_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 76.3 32 Yes Yes
2 bound 2.27 65.6 28.5 No No
3 empty 1.88 73.2 19.2 No No
4 bound 1.92 66.1 23.9 No No
5 empty 1.91 66.3 20.3 No No
6 empty 2.22 63.7 20.8 No No
7 empty 2.44 60.9 24.9 No No
8 empty 2.33 58.8 18.8 No No
9 empty 2.05 59.9 17.6 No No
10 empty 2.02 66.1 15.6 No No
4AN1_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 78 29.5 Yes Yes
2 bound 2.41 62.9 33.4 No No
3 empty 1.76 66.8 25.5 No No
4 empty 2.29 58.7 30.4 No No
5 empty 1.82 62.5 25.3 No No
6 bound 2.07 78.7 14.2 No No
7 empty 2.45 62.2 20.3 No No
8 empty 1.98 68.9 14.7 No No
9 empty 1.78 66.7 16.9 No No
10 empty 1.79 61.2 14 No No
1QFM_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 82.6 32.1 Yes Yes
2 empty 2.39 63.6 28.4 No No
3 empty 2.48 58.4 26.2 No No
4 empty 1.9 66.5 21 No No
5 empty 2.06 64.7 23.8 No No
6 empty 2.42 63 25.3 No No
7 empty 1.82 64.8 20.1 No No
8 empty 1.73 68.3 12.6 No No
9 bound 2.13 68.5 15.7 No No
10 empty 2.39 60.2 16.4 No No
4BCC_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 78.4 29.3 Yes Yes
2 empty 1.8 66.9 24.2 No No
3 empty 1.89 64.3 23.8 No No
4 empty 2.53 63.7 21 No No
5 bound 2.02 77.9 14.6 No No
6 empty 2.4 55.2 27.3 No No
7 bound 1.83 59.4 18.3 No No
8 empty 2.05 68.9 23.6 No No
9 empty 2.46 62.5 25.6 No No
10 empty 1.83 61.4 16 No No
1QFS_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 78.9 59.8 Yes Yes
2 empty 2.23 65.1 32.7 No No
3 empty 2.25 66 30.3 No No
4 empty 2.39 60.8 29.3 No No
5 empty 2.09 71 24.3 No No
6 empty 1.8 69.2 36 No No
7 empty 2.33 66.3 26.8 No No
8 empty 1.76 69 18.6 No No
9 empty 2.32 68.1 23.2 No No
10 empty 2.04 66.3 18.7 No No
3EQ8_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 78.6 56.8 Yes Yes
2 empty 1.97 67.7 24.7 No No
3 empty 2.15 65.7 33.6 No No
4 empty 1.95 68.3 35.7 No No
5 empty 2.15 67.6 22.6 No No
6 empty 2.19 57.2 29 No No
7 empty 2.2 65.1 23.8 No No
8 empty 2.6 64.2 16.7 No No
9 empty 2.39 67.6 20.2 No No
10 empty 2.24 66.3 25.4 No No
1E5T_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 78.8 30.3 Yes Yes
2 bound 2.36 61.5 32.8 No No
3 empty 1.87 65.5 25.3 No No
4 empty 1.98 58.7 29.9 No No
5 empty 2.5 59 30.5 No No
6 bound 2.05 80.5 16.5 No No
7 empty 1.92 73.5 21.6 No No
8 empty 2.52 61.8 19.8 No No
9 empty 1.96 59.4 17.3 No No
10 empty 1.8 59.5 20.6 No No
4AMY_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 78.1 29.2 Yes Yes
2 empty 2.41 62.7 32.8 No No
3 empty 1.94 64.2 26.5 No No
4 bound 2 78.4 14.5 No No
5 empty 2.5 61.9 24.6 No No
6 empty 2.42 56.2 27.3 No No
7 empty 2.01 67.9 25.4 No No
8 empty 1.67 68.1 15.1 No No
9 empty 2.04 63.7 17.7 No No
10 empty 1.66 61.2 21.1 No No
1H2W_A Prolyl endopeptidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 78.4 59 Yes Yes
2 empty 2.33 66.1 32.5 No No
3 empty 2.07 69.4 20 No No
4 empty 1.72 68.7 27.2 No No
5 empty 2.3 64.1 29.2 No No
6 empty 1.89 68.3 32.1 No No
7 empty 2.08 67.1 28 No No
8 empty 2.49 65.4 25.9 No No
9 empty 2.4 64.5 34.4 No No
10 empty 2.11 67.8 18.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed37
Domains assessed as druggable using the strict criteria26
Domains assessed as druggable using the relaxed criteria37

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1E5T_A (34644) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.4Å Yes Yes
1E5T_A (27676) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.4Å Yes No
1E8M_A (34642) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.5Å Yes No
1E8M_A (27674) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.5Å Yes Yes
1E8N_A (27675) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.5Å Yes No
1E8N_A (34643) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.5Å Yes Yes
1H2W_A (76597) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.39Å Yes Yes
1H2W_A (76596) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.39Å Yes Yes
1H2X_A (76598) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.49Å Yes Yes
1H2X_A (76599) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.49Å Yes Yes
1H2Y_A (76600) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.78Å Yes No
1H2Y_A (76601) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.78Å Yes Yes
1H2Z_A (76603) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.65Å Yes Yes
1H2Z_A (76602) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.65Å Yes Yes
1O6F_A (81085) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.6Å Yes No
1O6F_A (81086) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.6Å Yes Yes
1O6G_A (81088) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.4Å Yes Yes
1O6G_A (81087) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.4Å Yes No
1QFM_A (27673) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.4Å Yes No
1QFM_A (34641) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.4Å Yes Yes
1QFS_A (34645) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 2Å Yes Yes
1QFS_A (27677) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 2Å Yes No
1UOO_A (99699) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 2.35Å Yes Yes
1UOO_A (99698) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 2.35Å Yes No
1UOP_A (99700) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.85Å Yes Yes
1UOP_A (99701) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.85Å Yes Yes
1UOQ_A (99702) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 2.1Å Yes No
1UOQ_A (99703) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 2.1Å Yes Yes
1VZ2_A (108945) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 2.2Å Yes Yes
1VZ2_A (108946) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 2.2Å Yes Yes
1VZ3_A (108947) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 1.6Å Yes Yes
1VZ3_A (108948) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.6Å Yes Yes
2XDW_A (3270360) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, UNMATCHED 1.35Å Yes No
2XDW_A (3270361) Prolyl endopeptidase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Prolyl oligopeptidase C-terminal domain 1.35Å Yes Yes
3EQ7_A (4070866) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 2.89Å Yes Yes
3EQ8_A (4142996) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 2.72Å Yes Yes
3EQ9_A (4126848) Prolyl endopeptidase 7-bladed beta-propeller, Peptidase/esterase gauge domain, Prolyl oligopeptidase N-terminal domain 2.47Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score