Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PREP (P23687) - Overview - Molecular Target Synopsis

Protein


PREP, Prolyl endopeptidase
Enzyme Classification 3.4.21.26
UniProt P23687

Also Known as PPCE_PIG, PREP

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

4BCD
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON- COVALENTLY BOUND P2-SUBSTITUTED N-ACYL-PROLYLPYRROLIDINE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for PREP

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
710P23687-1

Sub-cellular localization


UniProt: PREP is active in the following subcellular-locations: cytoplasm.
GO terms: PREP is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PREP has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PREP there are:
28 structures (28 chains) solved
17 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PREP has been screened with 169 compounds (207 bioactivities), 147 compounds have bioactivities that show binding affinity of <= 500nM (181 bioactivities). (see details)