Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC8A1 (P23685) - Overview - Molecular Target Synopsis

Protein


SLC8A1, Sodium/calcium exchanger 1
UniProt P23685

Also Known as NAC1_CANLF, SLC8A1, NCX1

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.

6BV7
NMR STRUCTURE OF SODIUM/CALCIUM EXCHANGER 1 (NCX1) TWO-HELIX BUNDLE (THB) DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for SLC8A1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
970P23685-1

Sub-cellular localization


UniProt: SLC8A1 is active in the following subcellular-locations: cell membrane, sarcolemma.
GO terms: SLC8A1 is active in the following subcellular-locations: integral component of plasma membrane, intrinsic component of plasma membrane, nucleoplasm, postsynapse, sarcolemma.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC8A1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SLC8A1 there are:
8 structures (9 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC8A1 has been screened with compounds ( bioactivities). (see details)