Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTPRG (P23470) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed27
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria24


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3QCG_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 65.6 48.4 Yes No
2 empty 2.39 70.1 23.6 No No
3 bound 2.03 70.8 19.8 No No
4 empty 2.52 66.3 23.8 No No
5 empty 2.07 60.3 14.6 No No
6 empty 2.18 68.2 17.4 No No
7 empty 1.71 51.9 18.6 No No
8 empty 2.43 67.7 18.9 No No
9 empty 2.36 60.1 19 No No
10 empty 2.59 58.7 16.4 No No
3QCB_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 65.9 25.2 Yes No
2 bound 2.21 69.1 19.1 No No
3 empty 2.25 67.4 20.5 No No
4 empty 2.25 58.5 23 No No
5 empty 1.99 62.3 28.4 No No
6 empty 2.28 67.1 16.1 No No
7 empty 2.42 67.6 16.8 No No
8 empty 1.96 66.5 14.8 No No
9 bound 1.99 63.9 17.7 No No
10 empty 2.39 60 19.3 No No
2PBN_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 64.3 34.9 Yes No
2 empty 2.08 65.3 26.3 No No
3 bound 2.18 71.3 23.5 No No
4 empty 2.25 65.3 28.4 No No
5 empty 2.26 72.8 23.6 No No
6 empty 2.32 61.9 22.3 No No
7 empty 2.53 64.1 21 No No
8 empty 1.95 56.8 19.4 No No
9 empty 2.12 59.5 17.8 No No
10 empty 2 71.7 13.1 No No
3QCF_B Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 75.1 27.4 Yes No
2 empty 2.53 65.4 29.9 No No
3 empty 2.24 65.7 28.4 No No
4 empty 2.33 72.5 15.6 No No
5 empty 1.98 67 14.7 No No
6 empty 2.72 65.6 17.5 No No
7 empty 2.33 56.7 22.5 No No
8 empty 2.05 63.5 11.2 No No
9 empty 2.25 63.5 11.6 No No
10 empty 2.25 64.3 12.4 No No
3QCM_A Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 75.3 32.5 Yes Yes
2 empty 2.29 61.8 48.3 No No
3 empty 2.28 68.3 26.4 No No
4 empty 2.09 67.1 19.8 No No
5 empty 2.45 64.3 22.6 No No
6 empty 2.27 67.9 15.1 No No
7 empty 2.3 71.8 15.2 No No
8 empty 2.38 59.4 24.5 No No
9 empty 1.97 64.8 18.1 No No
10 empty 2.61 59.6 13.9 No No
3JXH_C Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 66 35.4 Yes No
2 empty 2.13 68.2 23.7 No No
3 empty 2.31 69.5 12.8 No No
4 empty 2.32 65.2 20.6 No No
5 empty 2.23 60.9 19.3 No No
6 empty 2.27 61.1 10 No No
7 empty 2.44 60.4 13.6 No No
8 empty 2.5 60.8 15.7 No No
9 empty 1.92 61.6 10.7 No No
10 empty 2.38 65 11.9 No No
2HY3_B Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 58.4 38.2 Yes No
2 empty 2.14 64.7 26.8 No No
3 empty 2.14 64.9 22.7 No No
4 bound 2.1 69.6 21.3 No No
5 empty 2.19 69.3 22.9 No No
6 empty 2.32 62.2 22.7 No No
7 empty 2.29 59.1 18.6 No No
8 empty 2.37 63.5 24.4 No No
9 empty 2.33 60.9 17.4 No No
10 empty 2.4 61.8 11.6 No No
2H4V_B Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 63.7 32.9 Yes No
2 bound 2.28 68.2 31.5 No No
3 empty 2.06 77 13.7 No No
4 empty 2.42 60.6 22 No No
5 empty 1.96 73.3 16.6 No No
6 empty 2.02 62.5 18.9 No No
7 empty 2.25 56.8 16.6 No No
8 empty 2.16 66.7 7.7 No No
9 empty 2.47 62 22 No No
10 empty 1.8 60.1 12.7 No No
2HY3_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 65.9 26.9 Yes No
2 empty 2.13 65.5 26.6 No No
3 empty 2.7 63.7 32.8 No No
4 empty 2.36 60.1 29.5 No No
5 bound 2.09 67.9 20.5 No No
6 empty 2.29 64.2 28.7 No No
7 empty 2.58 66.8 22.3 No No
8 empty 2.57 58.9 27.4 No No
9 empty 2.34 60.8 12.1 No No
10 empty 2.36 64.5 9.7 No No
3QCL_A Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 69.3 35.9 Yes Yes
2 empty 2.19 65.1 51.7 No No
3 empty 2.27 65.5 32.2 No No
4 empty 2.29 66.6 26.7 No No
5 empty 2.43 67.4 22.2 No No
6 empty 2.23 60.6 17.7 No No
7 empty 2.15 60.5 17 No No
8 empty 2.21 67.4 13.4 No No
9 empty 2.27 69.2 11.6 No No
10 empty 2.2 62.8 12.8 No No
3QCK_A Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 73.6 29.3 Yes Yes
2 empty 2.08 66.3 42.7 No No
3 empty 2.18 64.9 30.7 No No
4 empty 2.3 68.5 16.1 No No
5 empty 2.45 67.9 21.3 No No
6 empty 2.38 68.4 16.3 No No
7 empty 2.24 64.8 18.8 No No
8 empty 2.42 61.4 18.6 No No
9 empty 2.04 59.4 14.8 No No
10 empty 2.12 61.8 17.5 No No
3QCC_B Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 63.6 27.6 Yes No
2 empty 2.1 61.5 17.4 No No
3 empty 2.43 62.6 32.8 No No
4 empty 2.04 61.9 18.8 No No
5 empty 2.25 66.1 18.3 No No
6 empty 1.99 60.7 18.2 No No
7 empty 2.06 67.1 13.9 No No
8 empty 2.47 68.6 15.5 No No
9 empty 2 59.7 15.7 No No
10 bound 2.07 68 13.1 No No
3QCN_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 66.7 41.2 Yes No
2 empty 2.52 65.4 35 No No
3 empty 2.16 60 27.3 No No
4 empty 2.01 80.7 14.2 No No
5 empty 2.35 69.8 23.8 No No
6 empty 2.01 70.1 13.9 No No
7 empty 2.45 62.1 17.3 No No
8 empty 2.14 63.2 18.1 No No
9 empty 2.51 71.8 17.7 No No
10 empty 2.32 63.9 11.8 No No
3QCE_A Receptor-type tyrosine-protein phosphatase gamma No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 65.4 21.4 No No
2 empty 2.15 73.3 19.2 No No
3 empty 2.32 65.9 20 No No
4 bound 2.07 74.4 12.8 No No
5 empty 2.43 71.6 14.9 No No
6 empty 2.16 73.4 11.5 No No
7 empty 2.18 63.4 15.8 No No
8 empty 2.4 64.4 20.6 No No
9 empty 2.18 61.7 17.5 No No
10 empty 2.49 59.4 12.1 No No
3QCH_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 72 32.8 Yes No
2 empty 2.21 67.3 30.2 No No
3 empty 2.15 65 36.6 No No
4 empty 2.22 60.7 21.2 No No
5 empty 2.49 68.1 21 No No
6 empty 2.17 60.6 19.5 No No
7 empty 2.24 64.6 16.4 No No
8 empty 2.08 65.7 15.5 No No
9 empty 2.57 71.2 17.8 No No
10 empty 2.19 68.8 14 No No
3QCB_B Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 62.6 34.4 Yes No
2 empty 2.28 68.2 27.8 No No
3 empty 2.21 63.7 28.2 No No
4 bound 2.01 71.3 18.2 No No
5 empty 2 60.8 19.4 No No
6 empty 2.32 58.1 21.5 No No
7 empty 2.26 68.3 13.9 No No
8 empty 2.14 57.8 16.7 No No
9 empty 2.2 60.3 15 No No
10 bound 1.89 64.6 16.6 No No
3QCM_B Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 76.8 30.5 Yes Yes
2 empty 2.12 61.5 49.7 No No
3 empty 2.33 67 25.7 No No
4 empty 2.34 70.8 12.5 No No
5 empty 1.96 65.9 15.7 No No
6 empty 2.48 71.2 13.7 No No
7 empty 2.06 62.2 19.5 No No
8 empty 2.48 59.4 25.5 No No
9 empty 2.56 59.3 16 No No
10 empty 2.58 59.1 13.7 No No
3QCD_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 66 26.1 Yes No
2 empty 2.09 67.8 21.4 No No
3 bound 2.07 71.3 28.8 No No
4 empty 2.45 65.8 23.9 No No
5 empty 2.23 58.9 21.9 No No
6 empty 2.3 70.2 16 No No
7 empty 2.59 61.9 20.6 No No
8 empty 2.57 56.9 19.1 No No
9 empty 2.18 63.8 16 No No
10 empty 2.24 63.9 15.9 No No
3QCF_A Receptor-type tyrosine-protein phosphatase gamma No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 66 23.3 No No
2 empty 2.11 67.8 34.6 No No
3 bound 2.22 76.2 14 No No
4 empty 2.36 68.4 15.9 No No
5 empty 2.16 72.1 10.8 No No
6 empty 2.04 66.7 15.6 No No
7 empty 2.01 69.7 14.3 No No
8 empty 2.47 62.8 22.3 No No
9 empty 2 63.8 15.9 No No
10 empty 2.48 60.9 13.6 No No
3QCE_B Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 62.6 35.1 Yes No
2 bound 1.77 75.7 28.3 No No
3 empty 2.01 66.1 27.8 No No
4 empty 2.2 73.8 13.8 No No
5 empty 2.05 63.1 24.3 No No
6 empty 2.63 66 20.2 No No
7 empty 2.02 61.5 16.8 No No
8 empty 2.44 73.6 14.5 No No
9 empty 1.82 55.4 17.5 No No
10 empty 1.93 63.3 13 No No
3QCI_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 74.3 33.5 Yes No
2 empty 2.14 65.3 31 No No
3 empty 2.05 66.3 34.7 No No
4 empty 2.48 70.2 22.6 No No
5 empty 1.84 62.9 14.4 No No
6 empty 2.22 61.3 23.8 No No
7 empty 2.1 62.3 18.5 No No
8 empty 2.02 64.4 12.5 No No
9 empty 2.2 68.8 13.9 No No
10 empty 2.27 65.1 11.6 No No
3QCC_A Receptor-type tyrosine-protein phosphatase gamma No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 69.4 22.6 No No
2 bound 2.26 69.2 21.4 No No
3 empty 2.08 64.3 22.9 No No
4 empty 2.23 68.8 22.7 No No
5 empty 2.18 62.7 27.5 No No
6 empty 2.38 65.6 22 No No
7 empty 2.07 60.8 25.1 No No
8 empty 1.95 56.1 20.2 No No
9 empty 2.33 63.8 22.1 No No
10 empty 2.25 63.6 11.7 No No
5E5R_C Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 67.4 42.9 Yes Yes
2 empty 2.44 62.8 29.5 No No
3 empty 2.14 67.4 18 No No
4 empty 1.84 67 16.6 No No
5 empty 2.25 65.6 16.6 No No
6 empty 2.45 66 10.6 No No
7 empty 2.46 62.8 9.6 No No
8 empty 2.16 68.2 10.7 No No
9 empty 1.98 75.7 7.2 No No
10 empty 2.47 52.4 12.3 No No
5E5R_A Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 69 43.2 Yes Yes
2 empty 2.18 67.1 19.1 No No
3 empty 2.28 77.4 13.3 No No
4 empty 2.1 63.5 13.7 No No
5 empty 2.33 64.1 18.9 No No
6 empty 2.15 71.5 11.8 No No
7 empty 2.33 56.6 13.5 No No
8 empty 2.1 62.2 14.2 No No
9 empty 1.35 60.6 9.4 No No
10 empty 2.24 59.4 9.5 No No
2NLK_A Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 68.6 37.4 Yes Yes
2 empty 1.93 65.4 35.5 No No
3 empty 2.22 70.1 20 No No
4 empty 2.07 67.2 18.7 No No
5 empty 1.99 65.8 35.2 No No
6 empty 2.21 69.7 23.4 No No
7 empty 2.06 64.1 23.4 No No
8 empty 2.57 62.9 27 No No
9 empty 2.14 65 24.6 No No
10 empty 1.74 63.2 20.3 No No
3QCJ_A Receptor-type tyrosine-protein phosphatase gamma Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 70.8 33.4 Yes Yes
2 empty 2.29 67.2 42.5 No No
3 empty 2.15 64.7 32.9 No No
4 empty 2.35 64.3 17.8 No No
5 empty 2.25 62.4 19 No No
6 empty 2.34 68.2 23.5 No No
7 empty 2.39 59.8 20 No No
8 empty 1.86 67.4 12.5 No No
9 empty 2.46 69 19.1 No No
10 empty 2.29 67.9 12.9 No No
2H4V_A Receptor-type tyrosine-protein phosphatase gamma Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 71.4 20.3 Yes No
2 empty 2.11 56.5 23.6 No No
3 bound 2.11 70.2 20.8 No No
4 empty 2.18 63.5 20.9 No No
5 empty 1.81 58.6 20 No No
6 empty 2.13 61.3 23.8 No No
7 empty 2.13 65.1 17.6 No No
8 empty 2.29 64.4 18.9 No No
9 empty 2.47 56.2 13.7 No No
10 empty 2.05 66.7 15 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed7
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2H4V_A (3100736) Receptor-type tyrosine-protein phosphatase gamma (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 1.55Å Yes No
2HY3_A (3110641) Receptor-type tyrosine-protein phosphatase gamma (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 2.6Å Yes No
2NLK_A (3150463) Receptor-type tyrosine-protein phosphatase gamma (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 2.4Å Yes No
2NLK_A (3150464) Receptor-type tyrosine-protein phosphatase gamma UNMATCHED, UNMATCHED, UNMATCHED 2NLK 2.4Å No No
2NLK_A (3150465) Receptor-type tyrosine-protein phosphatase gamma (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, UNMATCHED 2.4Å Yes Yes
2PBN_A (3170632) Receptor-type tyrosine-protein phosphatase gamma (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Higher-molecular-weight phosphotyrosine protein phosphatases 1.7Å Yes No
3JXH_C (3490331) Receptor-type tyrosine-protein phosphatase gamma Carbonic anhydrase, Carbonic anhydrase, UNMATCHED 1.7Å Yes No
Ligand-based Druggability Score: -1.1
Ligand-based Druggability Score Percentile: 67%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PTPRG is involved in 26 interactions in the network.


Druggability
Overall Druggability Percentile: 98.30
Druggability for Cancer Therapeutics: 98.25
Druggability for Other Therapeutics: 94.29
Cancer-Associated
Cancer-associated percentile : 97.29
Network Articulation Point
Is PTPRG critical for communication in the network?


Detailed Graph Legend:Help