Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTPRG (P23470) - Overview - Molecular Target Synopsis

Protein


PTPRG, Receptor-type tyrosine-protein phosphatase gamma
Enzyme Classification 3.1.3.48
UniProt P23470

Also Known as PTPRG_HUMAN, PTPRG, PTPG

Possesses tyrosine phosphatase activity. Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.

5E5R
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBONIC ANHYDRASE-LIKE DOMAIN OF PTPRG AND IMMUNOGLOBULIN DOMAINS 2-3 OF CNTN3
RCSB/PDB
Inspect Structure
See all 3D Structures for PTPRG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1445ENSG00000144724ENST00000474889ENSP00000418112P23470-1
1416ENSG00000144724ENST00000295874ENSP00000295874P23470-2

Sub-cellular localization


UniProt: PTPRG is active in the following subcellular-locations: membrane.
GO terms: PTPRG is active in the following subcellular-locations: extracellular exosome, integral component of plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTPRG has gain in 2 cell-lines, loss in 7 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, 786_0, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 699, RERF-LC-OK, SUM 1315M02

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, BJ

(see details)

3D Structures


For PTPRG there are:
19 structures (27 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PTPRG has been screened with 39 compounds (47 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)