GLRA2 (P23416) - Overview - Molecular Target Synopsis
GLRA2, Glycine receptor subunit alpha-2
Also Known as GLRA2_HUMAN, GLRA2
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). Homopentamer (in vitro). Interacts with GLRB (PubMed:16144831). Heteropentamer composed of GLRA2 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed:15302677).
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UniProt: GLRA2 is active in the following subcellular-locations: cell junction, cell membrane, cell projection, postsynaptic cell membrane, synapse.
GO terms: GLRA2 is active in the following subcellular-locations: cell junction, chloride channel complex, glycinergic synapse, integral component of plasma membrane, neuron projection, plasma membrane, postsynaptic membrane, synapse.