Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CA6 (P23280) - Overview - Molecular Target Synopsis

Protein


CA6, Carbonic anhydrase 6
Enzyme Classification 4.2.1.1
UniProt P23280

Also Known as CAH6_HUMAN, CA6

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

3FE4 deposition date (2008-11-27)
CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE VI
RCSB/PDB
Inspect Structure
See all 3D Structures for CA6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CA6 is active in the following subcellular-locations: secreted.
GO terms: CA6 is active in the following subcellular-locations: extracellular exosome, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CA6 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SN12C, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DU4475, Hs 695T, SK-MEL-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


CA6 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For CA6 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CA6 has been screened with 483 compounds (832 bioactivities), 94 compounds have bioactivities that show binding affinity of <= 500nM (250 bioactivities). (see details)