Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AMPD1 (P23109) - Overview - Molecular Target Synopsis

Protein


AMPD1, AMP deaminase 1
Enzyme Classification 3.5.4.6
UniProt P23109

Also Known as AMPD1_HUMAN, AMPD1

AMP deaminase plays a critical role in energy metabolism. Homotetramer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: AMPD1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AMPD1 has gain in 8 cell-lines, loss in 3 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, MCF7, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H929, A4/Fuk, LP-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to AMPD1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AMPD1 has been screened with 11 compounds (11 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)