Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

trmA (P23003) - Overview - Molecular Target Synopsis

Protein


trmA, tRNA/tmRNA (uracil-C(5))-methyltransferase
Enzyme Classification 2.1.1.-
UniProt P23003

Also Known as TRMA_ECOLI, trmA

Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

3BT7
STRUCTURE OF E. COLI 5-METHYLURIDINE METHYLTRANSFERASE TRMA IN COMPLEX WITH 19 NUCLEOTIDE T-ARM ANALOGUE
RCSB/PDB
Inspect Structure
See all 3D Structures for trmA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: trmA is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project trmA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For trmA there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis