Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A5 (P22732) - Overview - Molecular Target Synopsis

Protein


SLC2A5, Solute carrier family 2, facilitated glucose transporter member 5
UniProt P22732

Also Known as GTR5_HUMAN, SLC2A5, GLUT5

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC2A5 is active in the following subcellular-locations: apical cell membrane, cell membrane, sarcolemma.
GO terms: SLC2A5 is active in the following subcellular-locations: apical plasma membrane, extracellular exosome, integral component of plasma membrane, plasma membrane, sarcolemma, specific granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A5 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, SNB_75, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HNT-34, NCI-H929, Pfeiffer

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, CD34-positive mobilized cell, SK-N-SH

(see details)

3D Structures


At greater than 75% identity similarity to SLC2A5 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A5 has been screened with 1 compounds (2 bioactivities). (see details)