Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CYP7A1 (P22680) - Overview - Molecular Target Synopsis

Protein


CYP7A1, Cholesterol 7-alpha-monooxygenase
Enzyme Classification 1.14.14.23
UniProt P22680

Also Known as CP7A1_HUMAN, CYP7A1, CYP7

Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.

3V8D
CRYSTAL STRUCTURE OF HUMAN CYP7A1 IN COMPLEX WITH 7-KETOCHOLESTEROL
RCSB/PDB
Inspect Structure
See all 3D Structures for CYP7A1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
504ENSG00000167910ENST00000301645ENSP00000301645P22680-1

Sub-cellular localization


UniProt: CYP7A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: CYP7A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, intracellular membrane-bounded organelle, organelle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CYP7A1 has gain in 10 cell-lines, loss in 5 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For CYP7A1 there are:
3 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CYP7A1 has been screened with compounds ( bioactivities). (see details)