Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

UBA1 (P22515) - Overview - Molecular Target Synopsis

Protein


UBA1, Ubiquitin-activating enzyme E1 1
Enzyme Classification 6.2.1.45
UniProt P22515

Also Known as UBA1_YEAST, UBA1

Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Monomer. Binds simultaneously two ubiquitin chains.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1024P22515-1

Sub-cellular localization


UniProt: UBA1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: UBA1 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project UBA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For UBA1 there are:
6 structures (12 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


UBA1 has been screened with compounds ( bioactivities). (see details)