Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P22513) - Overview - Molecular Target Synopsis

Protein


, Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Enzyme Classification 1.2.1.12
UniProt P22513

Also Known as G3PG_TRYCR

Homotetramer.

3IDS
STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM TRYPANOSOMA CRUZI IN COMPLEX WITH THE IRREVERSIBLE IODOACETAMIDE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
359P22513-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: glycosome.
GO terms: is active in the following subcellular-locations: glycosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
5 structures (20 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

is solved in complex with the approved drug(s):

CCS/CARBOCYSTEINE (3DMT_C).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with 47 compounds (75 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)