Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Ptgs1 (P22437) - Overview - Molecular Target Synopsis

Protein


Ptgs1, Prostaglandin G/H synthase 1
Enzyme Classification 1.14.99.1
UniProt P22437

Also Known as PGH1_MOUSE, Ptgs1, Cox-1, Cox1

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
602P22437-1

Sub-cellular localization


UniProt: Ptgs1 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: Ptgs1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, Golgi apparatus, intracellular membrane-bounded organelle, nuclear envelope, organelle membrane, photoreceptor outer segment.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Ptgs1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Ptgs1 has been screened with 421 compounds (619 bioactivities), 26 compounds have bioactivities that show binding affinity of <= 500nM (28 bioactivities). (see details)