Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RET1 (P22276) - Overview - Molecular Target Synopsis

Protein


RET1, DNA-directed RNA polymerase III subunit RPC2
Enzyme Classification 2.7.7.6
UniProt P22276

Also Known as RPC2_YEAST, RET1, RPC128, RPC2

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

6CNF
YEAST RNA POLYMERASE III ELONGATION COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RET1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1149P22276-1

Sub-cellular localization


UniProt: RET1 is active in the following subcellular-locations: nucleus.
GO terms: RET1 is active in the following subcellular-locations: nucleoplasm, RNA polymerase III complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RET1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RET1 there are:
15 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RET1 has been screened with compounds ( bioactivities). (see details)